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Signature Omega-3 Fish Oil Concentrate Review – Is it Effective?

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Overview | Nutrition Info | Warnings | Cost | Suggested Use | Final Thoughts

Signature Omega-3 Fish Oil Concentrate is a dietary supplement formulated to provide the necessary nutrients to maintain a healthy brain and heart. The active compounds used to create the Costco manufactured supplement also bring additional benefits to the joints, immune system, skin, and vision.

This formula is sold under the brand Kirkland Signature, the house brand of Costco Wholesale. The company is a retailer that commercializes various products in numerous categories such as appliances, clothing, hardware and auto, electronics, furniture, health and beauty products, sport, fitness, travel accessories, etc. They’re the same company behind Kirkland CoQ10.

The manufacturer of the formula is not disclosed for unknown reasons. A similar product sold under the same brand and containing 1200 mg fish-oil enteric-coated flavored softgels are also offered by the same retailer.

Signature Omega-3 Fish Oil Concentrate is formulated to use adults who want to improve certain aspects of their health (primarily memory, immunity, circulation, and bone density) or reduce symptoms of certain conditions (Alzheimer’s disease, heart disease, rheumatoid arthritis, etc.). The product does not contain artificial flavors or highly allergenic substances (yeast, starch, or gluten).

Signature Omega-3 Fish Oil Concentrate is marketed as a purified formula that lacks the toxic substances usually found in fish-oil based supplements: dioxins, furans, PCBs, and mercury.

The fish oil used as a raw material is derived from various fish species to maximize essential fatty and increase potency concentration.


1) Quick Overview

Signature Omega-3 Fish Oil Concentrate contains EPA (Eicosapentaenoic Acid) and DHA (Docosahexaenoic Acid).

EPA is believed to be effective in maintaining the health of the heart and circulatory system. The substance is used to treat and prevent coronary heart disease, lower triglycerides, cholesterol, high blood pressure, slow bone loss in elderly people, and reduced inflammation caused by rheumatoid arthritis.

The number of the claimed benefits in the case of EPA is impressive. Still, no conclusive evidence can fully support the benefit claims.

DHA is essential for the healthy development, growth, and functioning of the brain. Its importance in the growth and development of the central nervous system in unborn babies and infants is considered so high that today, most baby formulas and foods have been enriched with DHA.

However, the compound is also essential for maintaining normal cognitive function in adults. Decreased DHA levels in adults have been associated with cognitive impairment in the elderly and high cholesterol. DHA containing supplements were shown to improve memory in patients suffering from Alzheimer’s disease and healthy people (positively impacting both short and long term memory).

Usually, EPA and DHA based products have mild side effects like nausea or vomiting. The risk of bleeding may also occur in more severe cases (when excess amounts are consumed or the person suffers from certain conditions).

Signature Omega-3 Fish Oil Concentrate is not recommended for pregnant/ nursing women or people who suffer from blood clotting conditions without the consent of an informed healthcare specialist.

Nutrition Info

2) Ingredients of Signature Omega-3 Fish Oil Concentrate

Signature Omega-3 Fish Oil Concentrate contains the following ingredients: Natural Fish Oil Concentrate 1000 (EPA/DHA ), and other Omega 3, gelatin, glycerin, water, and Tocopherol.

3) Does Signature Omega-3 Fish Oil Concentrate Work?

Signature Omega-3 Fish Oil Concentrate combines the therapeutic effects of 2 essential Omega-3 fatty acids widely researched for their extended benefits on the overall health.

Numerous studies have shown that EPA and DHA may be useful in lowering cholesterol levels (due to their blood thinning properties), maintaining the brain and joints’ health, reducing symptoms of mood disorders like depression, and the risk of neurodegenerative diseases.

While EPA’s benefits on the heart and circulatory system are of utmost importance, DHA is considered essential for the growth and normal development of the central nervous system and vision in infants during their first years of life.

Fish oil is considered safe when consumed in the recommended doses (under 3 grams per day). Still, sometimes nausea, loose stool, rash, bloating, and burping may occur.

Higher doses may prevent blood clotting, which increases the risk of bleeding. This ingredient may interact with other drugs or worsen the symptoms of certain conditions such as bipolar disorder, HIV/AIDS, or allergies to seafood.

The supplement is not recommended for pregnant or nursing women, people with bleeding problems, under any medication that affects blood clotting, or those programmed to have surgery, unless the healthcare professional approves its use.

Many testimonials from consumers are available, and while most of them are positive, there are also complaints about the small doses of active compounds and side effects like indigestion or fish burps. The recommended dose is one soft gel taken two times a day, preferably after meals.

4) Signature Omega-3 Fish Oil Concentrate Benefits & Results

  • The formula is available with a reduced price for a month’s supply;
  • A money-back guarantee can be arranged;
  • Secured online purchasing is ensured;
  • Outstanding reputation of the manufacturer guarantees formula’s quality at some level;
  • A large number of testimonials can be accessed online.

5) Signature Omega-3 Fish Oil Concentrate Product Warnings

  • There’s a lack of research of the entire formula, like for most dietary supplements;
  • No free trial details are disclosed;
  • No information about the manufacturer is provided.

6) Signature Omega-3 Fish Oil Concentrate Cost

A bottle of this supplement comes at a relatively low price. It contains the necessary quantity for six months of use if the recommended dose is not exceeded (180 soft gels).

The product can be purchased online from the retailer’s official site but is also available at several other retailers. A full refund (including shipping and handling) is offered for unsatisfied clients. The product can be returned to any Costco warehouses or by postal services in the original package.

Only customers from US territory can order online on the official page. Standard shipping via UPS Ground does not generate additional taxes. A security protocol called SSL is used to guarantee the safety of online transactions.

Suggested Use

7) Suggested Use

The suggested use is 1 softgel two times daily after meals.

Final Thoughts

8) Final Thoughts on Signature Omega-3 Fish Oil Concentrate

Signature Omega-3 Fish Oil Concentrate offers a total of 300 mg of fatty acids per serving. Several organizations recommend daily allowances, but a dietary reference intake was not generally approved.

The consulted sources suggest that to be effective, the total amount of EPA and DHA combined should not exceed 500 mg per day.

The company behind this formula claims that all raw materials are guaranteed to pass the CRN standards in purity and safety. However, like most of the nutritional supplements, this is also is not approved by the FDA.

And while the brand is highly appreciated among consumers, it is impossible to determine the extent of the formula’s benefits in the long term.

4.3/5 - (3 votes)
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Paul C. Criner

This supplement was recommended by a colleague from work as a cheap and effective dietary supplement. He said it helped him to improve his memory and brain performance. So after I took the softgels for 3 weeks I started to notice the first improvements. I have been taking them daily and feel great! If it weren’t for the bad aftertaste I would say this is one of the most effective supplements I have taken.

Carla R. Latta

For me, this was the help I have always wanted but never got. I bought it after having read about the benefits of essential fatty acids on the brain, memory, and learning. Among its many other benefits, I can say that I can study more efficiently for exams and retain a lot more easy new information.