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L-Glutathione Review – 8 Things To Look For

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Summary | What's Inside? | Claims | Cautions | Price | How To Take | Bottom Line

L-Glutathione features as core active ingredients the molecule Glutathione, an amino acid stored in the liver. The formula is manufactured by Healthy Origins and is claimed to contain a brand of L-Glutathione called Setria, produced exclusively in Japan through a proprietary fermentation process. The formula hence is claimed to contain highest quality available Glutathione, although no evidence is provided to support this claim.

The manufacturer offers little information on the formula’s main benefits and ailment claims. The amino acid Glutathione has however been linked to potential benefits for the immune system, neurological and cognitive function, aging processes, cellular detoxification, etc.

Healthy Origins produces and markets a number of condition specific formula, tailored to assist with the particular needs of women and men, as well as for various ailments and health conditions that might impair the cognitive function, bone system, digestive system, cardiovascular function and other vital body systems and functions.


1) What is L-Glutathione?

L-Glutathione contains a single active ingredient, the amino-acid L-Glutathione, considered one of the body’s most important defense mechanisms against oxidative stress which leads to numerous ailments.
The amino-acid is produced by the liver, however after the age of 20, Glutathione levels decrease by 10-12% per decade making supplementation absolutely necessary.The antioxidant properties of this amino-acid are particularly important for the brain and neurological function, since brain generates an amount of oxidative by-products/gram of tissue larger than any other organ in the body. Most common uses, some of which have been investigates scientifically, include stroke, ischemia, Parkinson’s disease, Alzheimer’s, Down syndrome, sleep problems, toxicity of heavy metals, multiple sclerosis, lack of physical energy, inability to focus, etc.

What’s Inside?

2) What’s Inside L-Glutathione?

L-Glutathione includes the following ingredients: L-Glutathione Reduced, and gelatin (capsule).

3) What Does L-Glutathione Do?

L-Glutathione contains L-Glutathione, a molecule formed from three amino-acids. Glutathione synthesized in the liver and assists with various body functions including protein synthesis, DNA synthesis, and repair, amino acid transport, metabolism of toxins and carcinogens, immune system function, etc. Backed up by scientific evidence or not, Glutathione has been credited for preventing or treating a number of health conditions and ailments, including anemia, asthma, Alzheimer’s disease, cancer, AIDS, memory loss, high cholesterol, Parkinson’s, glaucoma, diabetes, mild cognitive impairment or Chronic Fatigue Syndrome to mention only a few. The molecule has antioxidant properties, hence the ability to scavenge free radicals and combat oxidative stress damage.

Many of its medical activities are still to be researched and proven through actual clinical trials. Side effects are rare and may include gastrointestinal discomfort, bronchial constriction, and allergies.

The recommended daily dosage is one capsule. There are testimonials posted online about L-Glutathione:

  • This has improved my brain health and cognitive function

  • I have more energy

  • I used it effectively for my heavy metals detoxification treatment

  • Keeps me going physically and mentally

  • It helped with my headaches


4) L-Glutathione Claims

  • The formula is free of sugar, salt, starch, yeast, wheat, gluten, corn, soy, barley, fish, shellfish, nuts, egg, dairy products, preservatives, artificial flavors or synthetic colors
  • Large number of generally positive consumer reviews
  • The Glutathione used is one of the highest quality available


5) What You Need to Know Before Taking L-Glutathione

  • The product comes with a moderate price (a month’s supply costs $25)
  • The limited number regarding certain health benefits of L-Glutathione
  • Little information offered by the manufacturer


6) L-Glutathione Price

The formula is available in 60 and 150 capsules bottles. A bottle of 60 capsules has a retail price of approximately $50, making a month’s supply cost roughly $25. However, most online retailers offer an up to 50% discount, and you may often find the 60 capsules bottle selling for approximately $22. The formula can also be purchased from the manufacturer’s website and numerous other online retailers and stores.

How To Take

7) How to Take L-Glutathione

The optimum recommended dosage is one capsule per day. No side effects are mentioned for L-Glutathione; although L-Glutathione may cause allergies, pr gastrointestinal problems. There are numerous consumer testimonials available online, most of which claim the formula helps with energy levels (mental and physical), detoxification, immunity system, and ultimately overall health.

Bottom Line

8) Our Bottom Line

L-Glutathione is an important antioxidant which fights oxidative stress damage. Levels of this amino-acid significantly decrease with age, hence it is essential to normal aging and prevention of diseases that might be cause by free radicals. L-Glutathione may be considered a safe and effective product, as numerous consumer reviews seem to claim. The formula is also advertised to be pharmaceutical grade and to contain the highest quality Glutathione (synthesized in Japan under a proprietary fermentation process).

3/5 - (2 votes)
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Quinn L.

I found that Healthy Origins L-Glutathione gives me immediate energy and also supports my stamina for the whole day. I mean both my physical and mental energy. The price is a bit high but I am convinced it is worth it!

Reply to  Quinn L.

How long after taking the supplement before you noticed any improvement?

Paula James

I attribute my improved mental alertness and memory cognitive to L-glutathione. I have also noticed that I have more energy and I get better rest.