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Total Memory Review – Is it Effective?

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Summary | Ingredients | Health Benefits | Side Effects | Warnings | Cost | Where to Buy? | How To Take | Bottom Line

AZOTH Total Memory is advertised as “the #1 rated brain supplement for focus, memory, clarity, energy, and memory decline.”

The formula contains Synapsa (a patented Bacopa monnieri extract), Huperzine A, and a small amount of Vitamin D3.

According to AZOTH, the company behind Total Memory, the ingredients in this brain supplement are “studied in over 100+ trials” and have proven to be the best cognitive support supplements on the market designed to “work on the first dose.”


1) What is Total Memory?

AZOTH Total Memory is one of the many brain supplements that promise instant, long-lasting results in terms of attention, focus, memory, mental clarity, energy, and overall cognitive support.

But can this simple formulation live up to the claims? Is it indeed proven to work in dozens of clinical trials as claimed by the manufacturer?

Before diving into our AZOTH Total Memory review, let’s see what science says about its core ingredient, Synapsa:

  • A 2012 double-blind, placebo-controlled, crossover study published in Phytotherapy Research[1] analyzed the benefits of Synapsa (CDRI 08) on sustained cognitive performance. In this study, 24 healthy volunteers completed six repetitions of the Cognitive Demand Battery (CDB) after consuming a placebo, 320 mg Bacopa monnieri (CDRI 08) or 640 mg of Bacopa monnieri (CDRI 08). Researchers observed improved performance in the group that received 320 mg of Bacopa monnieri (CDRI 08).
  • Steven Roodenrys, MD, conducted a randomized, double-blind, placebo-controlled 12-week trial[2] in 2002. The study was published in Neuropsychopharmacology, the official publication of the American College of Neuropsychopharmacology, and it demonstrated a significant effect of Synapsa (300mg/d) on the retention of new information by participants 40-65 years of age.
  • Another 2008 randomized, double-blind, placebo-controlled 90-day study[3] conducted by Con Stough, MD, examined the nootropic effects of Synapsa on human cognitive functioning. In this study, 62 participants, ages 18-60, received 300 mg of Synapsa daily. Synapsa showed a statistically significant improvement in visual information processing (sustained attention), working memory, and accuracy in complex cognitive tasks.

2) The Company Behind Total Memory

Total Memory is made by AZOTH LLC, an American brand founded in August 2017 by Prady Tewari.

The company has had success with an aggressive marketing strategy claiming to produce some of the “strongest nootropics on the market.” Despite its over-the-top claims, the sales have been skyrocketing; AZOTH LLC is currently selling products in over 38 countries.

Some popular nootropic supplements from this company include:

  • AZOTH 3.0 Total Brain
  • Total Focus
  • Total Memory
  • Pure Energy Zynamite

How to contact AZOTH LLC company:

  • Website: getazoth.com
  • Address: 1 Franklin St, Suite 1609, Boston, MA 02110
  • Phone: +1-617-213-0478

3) Total Memory Ingredients

Total Memory contains the following active ingredients:

  • Synapsa [Bacopa monnieri (whole-plant extract standardized to min. >55% Bacosides)] 320 mg
  • Vitamin D3 (as Cholecalciferol) 25 mcg
  • Huperzine A (Huperzia serrata leaf standardized extract) 100 mcg

Other inactive ingredients include rice flour, magnesium stearate, and vegetable capsule (microcrystalline cellulose).

Similar memory supplements like Jarrow Formulas PS 100 Phosphatidylserine use only one ingredient for more potency.

4) Does Total Memory Work?

In this next part of our Total Memory review, we will discuss some of the core ingredients included in the formulation, analyzing how these ingredients can benefit your cognitive health.

Let’s begin our assessment with Total Memory’s core ingredient.

The standardized extract of Bacopa monnieri known as Synapsa, often called CDRI-08 or KeenMind, is a trademark ingredient developed by the Central Drug Research Institute (CDRI) in India and distributed by PLT Health Solutions.

The CDRI is responsible for most of the clinical research conducted on Synapsa and for a large part of the research available on Bacopa monnieri.

Since, according to CDRI, Synapsa is a consistent and well-represented Bacopa monnieri extract, most scientific research on Bacopa has also been used to support claims on Synapsa.

However, the specifics on the extraction process for Synapsa aren’t entirely clear since most of it is hidden behind its patent.

In terms of benefits, Synapsa Bacopa may support cognitive health and functions related to learning, memory, and intellectual performance.

Huperzine A is a substance obtained from the Chinese club moss (Huperzia serrata), a plant used for centuries in Traditional Chinese Medicine to sharpen memory and reduce inflammation. Sold as a dietary supplement, Huperzine A is commonly used as a treatment[4][5] for Alzheimer’s disease.

Used in alternative medicine, Huperzine A has been discovered to act as a cholinesterase inhibitor, a type of medicine utilized to inhibit the breakdown of acetylcholine (a chemical essential to memory and learning).

Several clinical studies showed that Huperzine A might protect against age-related cognitive decline and enhance memory and learning[6][7][8].

Furthermore, Huperzine A is sometimes used to increase alertness, fight depression, boost energy, and help treat myasthenia gravis, an autoimmune disorder that affects the muscles. Still, the research[9] here is limited.

Vitamin D is required for optimal health. Most people get enough Vitamin D from sunlight or foods, but in some cases, supplementation with Vitamin D is also necessary.

If you have too little, you may become weaker, feel extremely tired, have muscle or joint pain, develop eczema, or a skin rash. Depression and high blood pressure are two long-term disorders associated with not getting enough Vitamin D.

Vitamin D3 offers many health benefits. It strengthens bones and muscles, improves mood, boosts immunity, improves heart function, and has anti-inflammatory effects.

Research has shown that Vitamin D3 might play an essential role in regulating mood and warding off depression.

In one study[10], scientists found that people with depression who received Vitamin D supplements noticed an improvement in their symptoms.

In another study[11] of people with fibromyalgia, scientists found that Vitamin D deficiency was more prevalent in those experiencing depression and anxiety.

Health Benefits

5) Total Memory Health Benefits

Total Memory claimed benefits include:

  • Rated #1 best brain focus and memory supplement
  • It contains ingredients studied in over 100+ clinical trials and proven to work
  • Works for people of all ages
  • Improves overall cognitive function and supports brain health
  • Improves focus, attention, and memory
Side Effects

6) Total Memory Side Effects

Given the ingredients available in this brain supplement, some individuals may experience mild to moderate adverse effects, typically due to how their bodies adjust to the supplement.

Total Memory side effects[12][13][14] may include:

  • Diarrhea
  • Nausea
  • Dry mouth
  • Vomiting
  • Sweating
  • Constipation
  • Slurred speech
  • Blurred vision
  • Restlessness
  • Fainting
  • Cramping
  • Loss of appetite
  • High blood pressure
  • Inability to control urination
  • Inability to sleep
  • Dizziness
  • Slowed heart rate

Total Memory contains Huperzine A. The available research indicates that Huperzine A is more likely to cause side effects and negative interactions with specific prescriptions when continuously taken for more than 30 days.

Therefore, we recommend cycling the supplement regularly, taking one week off every three weeks as a minimum. Longer breaks are advised after repeated cycles.


7) Total Memory Product Warnings

Some prescription medications that may interact[15][16] with AZOTH Total Memory include:

  • Medications for Alzheimer’s disease
  • Anticholinergic drugs, such as Atropine or Scopolamine
  • Medications that slow blood clottings, such as Plavix, Anaprox, or Coumadin
  • Medications for glaucoma
  • Anticonvulsants, such as Phenobarbital, Neurontin, Dilantin, or Mysoline
  • Medications for diabetes, such as Avandia, Glynase, or Amaryl
Where to Buy?

8) Where to Buy Total Memory

AZOTH Total Memory is readily available at many online retailers. The nootropic can be purchased directly from AZOTH’s official website, but it may also be found in other online retailers, including Amazon, Walmart, eBay, and VitaminShoppe.


9) How Much Does Total Memory Cost?

One bottle of AZOTH Total Memory (30 capsules / 30 servings) is priced at $29.99.

How To Take

10) How to Take Total Memory

As a dietary supplement, take one (1) capsule daily, preferably with a light meal. Consistent daily use for a prolonged period of time with periodic breaks is recommended for best results. Do not exceed recommended dosage. Consult your healthcare provider before use.

11) What Users Are Saying

"I was starting a new job last week and knew I'd have a lot to take in. I just wanted something to help me not get a stress headache and be able to keep focus. I'm on the 5th day. And though I haven't got a headache, I didn't yet notice much of a "lightbulb" moment or feel more triggered to register information. I usually forget details and tasks. I am in a different environment altogether, so that helps, but I feel good overall about how I have been focused." [Read full review]


"I just started but noticed some improvement already. Also seem to have more focus and concentration. Less anxiety as well." [Read full review]

---L. Poquette

"As a server in a high-end restaurant, it's critical to know every ingredient in every dish to describe it and, more importantly, know exactly what people with allergic reactions should stay away from. If I go blank and can't remember what's in the dish, I'm going to look bad. My mom and sister took Total Memory and saw a difference, so I decided to try it. I don't know if it's a nervous thing, but so far, I haven't had any blank issues at work and feel confident that I will be sharp and on my game, which will affect my pockets." [Read full review]


Bottom Line

12) The Bottom Line – “Does it Work?”

AZOTH’s Total Memory features a relatively straightforward formula relying on three core ingredients, including 25 mcg of Vitamin D3 and 100 mcg of Huperzine A.

The third ingredient in this brain support supplement is Synapsa, a more concentrated, branded version of Bacopa monnieri. Total Memory offers 320 mg of Synapsa wrapped up with Vitamin D3 and Huperzine A in a single-capsule serving.

Price-wise, Total Memory is somewhere in the middle. While many users will not be deterred by the $29.99/month price tag, we believe better alternatives are available in this price range.

5/5 - (1 vote)

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