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Amen Clinics Restful Sleep Review – Is it Effective?

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Facts | Nutrition Facts | Health Benefits | Warnings | Cost | Directions | Does it Work

Restful Sleep is a dietary supplement formulated to support a restful sleep and to promote normal sleep patterns. The formula is offered by Amen Clinics, an institution specialized in treating a large variety of diseases including brain and memory related and behavioral disorders such as ADHD, ADD, anxiety and depression, memory issues, brain injury and autism. The person behind this product is Dr. Amen, a reputable physician and psychiatrist and founder of the Amen Clinics.

Restful Sleep is a blend of herbal extracts and vitamins combined in a formula which promotes a relaxed state of mind for a deep, restful sleep.According to the manufacturer, the uniqueness of this supplement resides in its ability to provide both immediate-release and time-release doses of melatonin, thus ensuring an all-night restful sleep.


1) Restful Sleep Quick Facts

Restful Sleep is an herbal and vitamin based formula combined with naturally occurring substances.

Melatonin is one of the product’s main active ingredients. It is a hormone secreted in the brain with an essential function in regulating other hormones and day-night cycle. It is believed to have strong antioxidant effects and to help with sleeping problems such as insomnia. However the results of clinical trials are yet inconclusive. Side effects commonly reported include morning grogginess, vivid dreams and lowered body temperature.

GABA is an essential neurotransmitter and plays an important role in the central nervous system proper functioning. The main function of GABA is that of regulating neuronal excitability – it inhibits nerve transmission in the brain promoting a relaxing state and reducing anxiety. Clinical test results are contradictory as some of them report that GABA taken as a supplement does not reach the brain and is no more effective than a placebo.

Nutrition Facts

2) Restful Sleep Nutrition Facts

Restful Sleep contains the following ingredients: Melatonin (immediate-release), Melatonin (controlled-release), GABA (Pharma GABA„), Valerian (Valeriana Officinalis, 0.8% Valerenic acid), Magnesium (glycinate), Vitamin B6 (pyridoxine HCL), gelatin capsules (gelatin, water and glycerin), Magnesium stearate, Silicon dioxide, and Magnesium silicate.

If you prefer a melatonin supplement in gummy form, check out our Natrol Melatonin Gummies review.

3) Does Restful Sleep Work?

Advertised as a remedy that should help people with sleeping problems, Restful Sleep contains melatonin in combination with GABA, valerian, magnesium and vitamin B6. Evidence has shown that melatonin helps control natural sleep-wake cycle. Some research suggests that melatonin supplements might be helpful in treating jet lag or reducing the time before falling asleep, although the effect is considered to be typical mild.

Melatonin might be more useful for other types of sleep issues, such as delayed sleep disorder or sleep disorders affecting circadian rhythm. Common side effects regarding the usage of melatonin include daytime sleepiness, dizziness, and headaches. Also, this ingredient can interact with various medications such as blood-thinning medication, birth control pills or immuno-suppressants.

Another component of Restful Sleep is GABA, one of the inhibitory neurotransmitters found in the mammalian central nervous system. It plays a role in regulating neuronal excitability in the nervous systems. GABA is also directly responsible for the regulating of muscles tone

GABA supplements are said to enhance mood and relaxation, improve sleep, relieve anxiety and stress, thus improving concentration. Side effects of GABA are mild and uncommon.

Health Benefits

4) Restful Sleep Health Benefits

  • Reputable developer of the formula
  • Discounts offered for monthly auto shipping
  • 100% money-back guarantee (the period of time is not specified)

5) Restful Sleep Product Warnings

  • No evidence or results of clinical trials on the whole formula
  • Relatively high price for a month’s supply (approximately $80)
  • No reviews available directly from consumers to support the formula’s effectiveness

6) How Much Does Restful Sleep Cost?

Restful Sleep is sold on manufacturer website and other online retailers. Its price might be considered moderate when bought in larger quantities, but expensive by the bottle, especially in comparison with similar products. A bottle contains 60 capsules. Thus it can last from 15 to 30 days of treatment, or even 60.


7) Restful Sleep Directions

Restful Sleep is recommended in doses of 4 capsules daily taken 30-60 minutes before bedtime.The selling company does not provide any test results to support the ailment claims for their product. Consumer testimonials are not available online therefore a clear assessment of the formula’s actual effectiveness cannot be made.

Does it Work

8) Bottom Line – Does It Really Work?

Restful Sleep is advertised as a unique formulation which promotes an all-night restful sleep and normal sleep patterns for its adult consumers.

The formula acts mainly by increasing the levels of melatonin, a hormone known to be essential for healthy sleeping habits and normal sleep-awake cycles.

The developer of the formula recommends their product as a dietary supplement or as directed by a healthcare professional. No precautions or warnings are issued regarding side-effects, misuse or interactions with other medication, although individual ingredients may actually interfere with normal body functions and produce side effects.

There is no reference to clinical testing results of the whole formula. More so, clinical tests involving the active ingredients have sometimes proven inconclusive or contradictory as regards to their benefits in helping with sleeping and/or anxiety disorders. In the absence of consumer reviews, we recommend you ask for a physician’s opinion prior to deciding to use the product.

4.3/5 - (3 votes)
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I have been using this supplement for three weeks now, it sometimes works, but not alwayas.

Claire J. Clay

Say GOODNIGHT. I really love this stuff…it helps me sleep during nights and wake up rested.


Does not work! I have better results with just melatonin. Has opposit effect on me, was very disappointed.