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Phosphatidyl Serine Review – 8 Things You Should Know

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Summary | Nutrition Facts | Claims | Contraindications | Price | Suggested Use | Verdict

Phosphatidyl Serine is a chemical naturally found in the human body and certain foods like soy and mackerel. This product, offered by Chicago-based Carlson Labs, is derived from sunflower oil. It’s a simple supplement containing 100 mg of phosphatidyl and doesn’t have much in the way of filler ingredients, unlike many brain-boosting supplements containing phosphatidyl. You know exactly what you get just by reading the label.

Carlson Labs has created hundreds of high-quality products since 1965. They seem to focus a lot on quality and delivering results to their customers. One of the things that makes them different is their apparent dedication to information. Their site has a vast amount of things to read, from coursework to recipe ideas and PDF booklets containing research.


1) What is Phosphatidyl Serine?

Although phosphatidyl is often lauded for its benefits in fighting age-related memory loss, and its applications for Alzheimer’s disease, its effects have also been studied in athletes. In general it can improve performance through decreasing the chance of muscle damage, improving the body’s resistance to stress, and promoting a desired hormone balance.

Nutrition Facts

2) Phosphatidyl Serine Nutrition Facts

Phosphatidyl Serine contains the following ingredients: Phosphatidyl Serine, Sunflower oil, maltodextrin (from tapioca), silicon dioxide, mixed tocopherols, ascorbyl palmitate, Soft Gel Shell: Beef gelatin, glycerin, water.

3) Is Phosphatidyl Serine Right for You?

Phosphatidyl is a chemical naturally found in your body, although much of your body’s needs are fulfilled from foods. Phosphatidyl-based supplements are often made from cabbage or soy and it’s key in maintaining cellular function. Phosphatidyl is especially useful in the brain, where it’s used to improve mental function. If taken in doses over 300 mg, some people report upset stomach and insomnia, but there don’t tend to be side effects. Each soft gel capsule of Phosphatidyl Serine only contains 100 mg so it’s definitely safe.

According to Carlson Labs, Phosphatidyl Serine promotes inter-cellular communication in the brain and aids the neurotransmitters involved in learning, memory, and mood. Studies on show that it seems to improve language skills, memory, and attention for people at risk of suffering from age-related mental decline. It also improves some symptoms of Alzheimer’s disease, and is most effective in people with less severe effects. Newer versions of phosphatidyl are still undergoing testing and they appear to have the same benefits. There’s some evidence for other benefits as well, such as improving depression and improving athletic performance, but more research needs to be done to verify these.

All in all, Phosphatidyl Serine might just give you the type of mental boost you need. It can work in people of all ages, although most research has been about its effects on the elderly, who tend to need medication to improve mental performance because of age and cognitive decline. If you’re currently taking prescription medicine, you should consult a doctor before taking phosphatidyl, since it can interact with other medications in unpleasant ways.


4) Phosphatidyl Serine Claims

  • 100 mg of phosphatidyl per capsule is supposed to be the exact amount most people will need to see positive effects and each bottle lasts for about a month.
  • Phosphatidyl Serine is inexpensive compared to other brands that claim to do similar things, and may have a higher level of purity.


5) Phosphatidyl Serine Warnings and Precautions

  • Each capsule is made from beef gelatin so it’s not entirely vegan friendly.
  • You might also have to take a lot more than the recommended serving size to feel the benefits. Since people are biologically different, some are fine with 100 mg and some need massive amounts of 500 mg or more. Phosphatidyl may also be more age-dependent than some other supplements.


6) Phosphatidyl Serine Price

Each bottle nets you about a month’s supply, so it’s a little expensive compared to other Carlson products, but for a cognitive enhancement supplement Phosphatidyl Serine is on the inexpensive side. Other brands who use phosphatidyl tend to have much higher prices and a less pure formula which often includes filler ingredients.

Suggested Use

7) Suggested Use

Deterioration from over-training can be lessened or eliminated with varying amounts of phosphatidyl. Recent studies have shown that it can enhance mood in people who are stressed, and improve accuracy among golfers when teeing off. More research is being done into phosphatidyl’s benefits related to sports nutrition, and so far it’s very positive. Aside from athletes, Phosphatidyl Serine shows promising results, especially in in older people who might be prone to experiencing age-related memory loss. It’s also noticeable for having positive effects in every age group from a variety of backgrounds.


8) Our Final Take On Phosphatidyl Serine

Carlson Labs says on their website that Phosphatidyl Serine promotes inter-cellular communication in the brain and aids the neurotransmitters involved in learning, memory, and mood. Almost all reviewers agree with this, saying phosphatidyl has done it’s promised to boost cognitive function. People of all ages have noted an increase in mental performance, including memory and focus. They do report needing different amounts, as is common with many types of supplements. Buying from Carlson Labs is also a safe bet because of their long history working with supplements and fish oils. They have a solid reputation for having reasonably priced products with a high level of quality.

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