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Huperzine Rx-Brain Review – 11 Facts You Need to Know

By Robert Rivera

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Synopsis | Nutrition Info | Benefits | Side Effects | Contraindications | Cost | How To Take | Final Thoughts

Huperzine-Rx Brain is advertised as a nootropic formulated with optimal brain function in mind, if you can call it a formula.

Unlike most of the nootropics we’ve reviewed, Huperzine Rx-Brain consists of only one ingredient: Huperzine. Huperzine itself is part of many high-quality formulations, but this is the first time we’ve seen it come in a standalone brand.

Huperzine is a decent nootropic that works well with just a tiny dose, but can it carry the claims its manufacturers make? Read our Huperzine Rx-Brain review to find out.


1) Huperzine Rx-Brain at a Glance

  • One-ingredient formula
  • Gluten-free, Vegetarian
  • Cost is relatively pricey for the formula

2) How Did Nature’s Plus Start?

The company behind Huperzine Rx-Brain is NaturesPlus. The company enjoys an experience that expands over more than 35 years and has earned a reputation as one of the best manufacturers of natural health products.

NaturesPlus is based in the US and operates a GMP-certified facility. They say their Quality Assurance Inspectors are stationed at every stage of production in order to maintain adherence to Nature’s Plus’ strict quality control guidelines.

You may contact NaturesPlus through the following:

  • Contact Form: https://naturesplus.com/pages/contact-us
  • Phone: 1-800-645-9500
Nutrition Info

3) Ingredients of Huperzine Rx-Brain

Huperzine-Rx Brain includes just one key ingredient:

Huperzine-A (from Huperzia Serrata)

Huperzine-A is the active component found in the rare species of Chinese moss, also known as Huperzia Serrata. Huperzine A is in fact the result of extensive laboratory manipulation and contains hundreds of chemical ingredients.

The extract seems to work by increasing levels of the neurotransmitter Acetylcholine, therefore it is thought to benefit memory and prevent loss of mental abilities and memory impairing conditions.

One other neat thing about Huperzine A is how it works with such a small dose, it barely tips the weighing scale. It allows Huperzine A to fit perfectly into almost every (if not all) nootropic formula.

There is no daily recommended dosage established for Huperzine A. However, doses of 50-200 mcg have been used for people with Alzheimer’s disease, and a 100 mcg daily dose is given to patients for improvement of memory skills in younger adults and adolescents.

Other inactive ingredients include: Di-calcium phosphate, microcrystalline cellulose, Stearic acid, Magnesium Stearate, silica, and pharmaceutical glaze.

4) Is Huperzine Rx-Brain Right for You?

It depends. Huperzine Rx-Brain only has one ingredient and while that one ingredient has solid evidence backing its effects on brain health, it’s still just one.

Most nootropic enthusiasts like taking something complex or something formulated to work on a variety of brain-related benefits and function.

If you like complex formulas, you will have to skip Huperzine Rx-Brain.


5) Huperzine Rx-Brain Benefits & Results

  • Hypo-allergic, vegetarian, gluten-free formula
  • Consumers report being satisfied with the supplement
  • Price is either affordable or a bit premium, depending on your goal
Side Effects

6) Huperzine Rx-Brain Side Effects

Common side effects of Huperzine A’s use are:

  • nausea,
  • blurred vision
  • sweating
  • restlessness
  • cramping
  • muscle contraction
  • high blood pressure
  • slow heart rate.

7) Huperzine Rx-Brain Warnings and Precautions

  • Potential side effects of associated to Huperzine A
  • The formula comes with certain precautions for some categories of individuals
  • More research is required to confirm the main ingredient’s benefits on memory and long term safety
  • A daily dose of Huperzine A is not clearly established
Where to Buy?

8) Where to Buy Huperzine Rx-Brain?

You can buy Huperzine Rx-Brain from the official NaturesPlus website, Amazon, and various online supplement stores.


9) How Much Does Huperzine Rx-Brain Cost?

One bottle of Huperzine Rx-Brain costs $13.80.

How To Take

10) How to Take Huperzine Rx-Brain

As a dietary supplement, one tablet daily with a meal or as recommended by your health care professional.

Final Thoughts

11) Final Thoughts on Huperzine Rx-Brain

Huperzine-Rx Brain promotes the benefits of Huperzine A, a chemical compound extracted from the plant Huperzia Serrata.

Much research is currently conducted to prove the herb’s effects on memory enhancement and in preventing and treating one of the most frequent neuro-degenerative disorders, Alzheimer’s disease.

Preliminary evidence indicates that certain combinations of Huperzine A and other drugs may be effective in treating these disorders and promoting increased memory capacity.

The formula is simple, but too simple in our opinion. The tablet has more non-key ingredients both in quantity and weight. The price seems affordable, but we think buyers deserve one or two more ingredients to justify the price.

Huperzine Rx-Brain is still a decent nootropic, but we’re not confident to recommend it over similarly priced formulas that have more than one ingredient.

While the evidence for Huperzine-A is quite strong, it’s imperative that you ask your physician before taking it for anything therapeutic.

3/5 - (2 votes)
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My brother uses this and is very pleased, I’ll give it a try too.

Lois J

I started using this a week ago and I already feel improvement, can’t wait to se how it develops.


Have been taking Hyperzine Rx Brain for several years with no negative side effects and enjoy marked improvement in my mental awareness, energy, and focus.