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EMPowerplus Review – Is it Effective?

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Synopsis | Nutrition Info | Cautions | Cost | Suggested Use | Verdict

EMPowerplus is advertised as a highly effective natural alternative for maintaining optimal mental health. The formula is created by Truehope Nutritional Support, an American independent producer of nutritional formulations since 1996. They are specialized in formulating products that are designed particularly to identify the core causes of mental illness and mood conditions. By identifying the causes instead of simply treating the symptoms, these supplements may provide long-term benefits for their users.

This formula is the single product included in the Advanced Natural Medicine line of supplements. Truehope’s EMPowerplus comes in three forms: the EMPowerplus Classic, the EMPowerplus Advanced, and the EMPowerplus Powders. Generically, the product is advertised as the most studied micronutrient in the world featuring next-generation compounds. The main difference between this formula and other brain boosters is that this formula is much easier assimilated in the brain due to the special processing technology called the Apex Biosynthesis Conversion Technology.

EMPowerplus ingredients include a total of 36 nutrients in the form of minerals, vitamins, and a proprietary blend of herbs, amino acids, and antioxidants, most of which are researched substances. This supplement is offered as a base daily supplement suitable for adults and children alike who suffer from conditions like depression, bi-polar disorder, anxiety, or ADHD.


1) EMPowerplus at a Glance

EMPowerplus is a multi-vitamin supplement features a large number of substances from various classes of compounds (vitamins, minerals, amino-acids, plant extracts).
The B-complex of vitamins is also present in the composition of this formula. This if formed from a total of 8 vitamins, each with specific functions within the body. However, when recommended together, the substances are believed to provide an overall support for the skin, heart and cognitive function, effective in alleviating depression and anxiety symptoms. The richest food sources of B vitamins are cereals, whole grains, eggs, nuts, kidney beans, bananas, and green leafy vegetables. Deficits in vitamins B cause various malfunctions in the body, resulting in symptoms like reduced appetite, mood problems, muscle cramps, hair loss, or skin disorders (mostly eczema). From all the B-vitamins, the most important for the brain is vitamin B12, which has been related to improved memory in both healthy and sick people (affected by degenerative disorders like Alzheimer’s disease).

Ginkgo Biloba is known as the oldest species of trees on the planet. The therapeutic properties of this plant are owed to a large amount of antioxidants present in its leaves. The compounds are known as flavonoids and terpenoids and have been clinically studied to determine the extent of their anti-oxidative properties. As an alternative remedy, Ginkgo Biloba extract is used in the treatment of a broad spectrum of symptoms, from memory decline (dementia, Alzheimer’s disease) to circulatory problems. Side effects of this herbal extract include nausea, dizziness, headaches, and increased risk of bleeding (Ginkgo Biloba has excellent blood thinning properties).
EMPowerplus side effects are not indicated by the manufacturer.

Nutrition Info

2) Ingredients of EMPowerplus

EMPowerplus contains the following ingredients: Vitamin A, Vitamin C, Vitamin D, Vitamin E, Vitamin B1, Vitamin B2, Vitamin B3, Vitamin B5, Vitamin B6, Vitamin B9, Vitamin B12, Calcium, Copper, Selenium, Phosphorus, Iodine, Zinc, Potassium, Magnesium, Iron, Molybdenum, Manganese, Chromium, Glutamine, Choline bitartrate, DL-phenylalanine, Citrus bioflavonoids, Grape Seed extract, Nickel chelate, Vanadium Chelate, Boron chelate, Germanium sesquioxide, Choline bitartrate, Inositol, L-methionine, L-glutamine, Ginkgo Biloba leaf, capsule shell (gelatin, titanium dioxide), microcrystalline cellulose, glycine, Magnesium stearate, citric acid, Silicon dioxide, and shilajit extract.

3) Is EMPowerplus Right for You?

EMPowerplus is a combination of more than 30 vitamins, minerals, amino acids and herbal extracts. We are usually skeptical when it comes to supplements with so many different ingredients. What concerns us is that a large number of combined ingredients could create and unhealthy level of toxicity in the body, which obviously is dangerous.

Besides that, the large number of ingredients, while some of them are useful, will not be able to pass through the blood-brain barrier, as the product does not contain the right combination of amino acids or neuro-nutrients to make this possible.

It is necessary for a brain supplement (or your diet) to have specific amino acids and the associated neuro-nutrients which the brain uses to maintain your neurotransmitters and hormones. Now you can see how just being “bombarded” with a collection of vitamins, minerals, herbs and random amino acids will not help you.

Nevertheless, this product appears to be somehow effective in treating the health problems mentioned above. Many users, especially those who have tried antidepressant or anti-bipolar disorder medications and noticed no effect, have reported some positive results after using this supplement.

Furthermore, the manufacturer has conducted several clinical studies and researches to support the Effectiveness of this treatment. The findings of these studies, though, aren’t fully discussed, and the company doesn’t explain how this formula is supposed to work. EMPowerPlus side effects may exist, though the manufacturer mentions none. These may result from the action of the individual ingredients and may include nausea, high risk of bleeding, dizziness, headaches, etc.

There are EMPowerPlus reviews posted online. What is being reported includes the following:

  • Life without this product is unimaginable, having faced years of manic episodes and anxiety.

  • I consider TrueHope EmpowerPlus, a true helper for my depression as well as for my son’s ADD.

  • The price is just a little above of what I can afford, but the benefits are worth it.

There are also some multivitamins designed for older men like One A Day Mens 50 Plus.

4) EMPowerplus Benefits & Results

  • The supplement offers a complete multivitamin, mineral and antioxidant support
  • The ingredients are clinically researched compounds
  • A 100% money-back guarantee is available in the first 30 days after ordering the formula
  • Online ordering is possible directly from the manufacturer’s site
  • The formula has been researched with encouraging results concerning its mental benefits (22 medical journals involving this supplement are available for downloading on the manufacturer’s web page).

5) What You Need to Know Before Taking EMPowerplus

  • The monthly price starts from a moderate price of $35 and may reach up to $70 for the Advanced formula, which is a high price for a multivitamin supplement
  • No free sample is offered by the manufacturer
  • EMPowerplus reviews are rare and consumers report mixed results

6) EMPowerplus Cost

A bottle of EMPowerplus contains 57 capsules, which should be enough for about one month of treatment for the average user. Compared with other similar products, this is a rather expensive supplement.

The product can be purchased directly from the manufacturer’s website (it requires an account) or from several online retailers.

The cost of shipping depends on the delivery location. Once the shipping address is entered into the system, the cost will be calculated. There is overnight and two-day shipping offered at an extra charge too.

It is crucial that orders have the correct shipping address on them. According to the website, any products that are returned due to failure to deliver will be restocked. A refund will be given, but less shipping charges and less a 25% restocking fee.

Suggested Use

7) Suggested Use

Aside from the reviews found on the official page, EMPowerplus reviews are mixed and in an unconvincing number, so a valid opinion regarding the potential side effects experienced and success of the formula among users cannot be currently issued. The suggested serving size is 4 capsules per day.


8) Our Final Take On EMPowerplus

The formula is a dietary supplement which at first sight does not seem any different from any other multivitamin formula. However, the product is marketed as obtained through unique processing techniques (micronization and chelation) and based on balanced amounts of compounds to ensure optimal nutrition for the body.

The manufacturer offers several personalized plans that involve the use of this product in combination with several other formulations offered for the treatment of the following disorders: depression, bipolar disorder, anxiety and panic, and ADD and ADHD.

EMPowerplus is also advertised to be an effective replacement of psychiatric drugs with fewer and less severe side effects. The formula is however an unapproved dietary supplement which does not seem to be the subject of a serious clinical trial. Most of the benefit claims do not check out unfortunately, since a limited number of consumer reviews is available and evidence derived from clinical trials is not published for the public to consult.

5/5 - (1 vote)
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Mr E

My wife was taking this for a while about 10 years ago. After following the suggestions, her body felt amazing, she was waking up with energy. However, her depression seemed eratic at best, despite her claims of feeling better. She soon became more and more aggressive and desperate until even she realized she wasn’t ok at all. I have no proof that it was the supplement but she was catatonic for the next year. It took a few years of getting her on the right antidepressants and therapy for her to get feeling better and to be fully functional again. Recently after years of doing very well she decided she wanted to start taking vitamins again and said she remembered how good her body felt on this. Shes been taking it for a few weeks now and has had a number of episodes over the last week or so. I’ve asked her if she thinks theres a connection. She doesn’t want to consider it. Please be careful people stuff can be damaging if it’s not working or you see bad effects please be flexible!

Title for your comment
Not all its cracked up to be
Have you tried this product?

Why is big pharma so against this alternative to psychotropic drugs that have disastrous side effects? Big pharma tried to squash this in Canada in 2016 and is thwarting every attempt to establish real studies by natural medicine institutions.

Title for your comment
Big pharma stop fighting progress
Have you tried this product?
Paggi Lancon

I have been taking Q96 for several months and it has changed my life immensely. My husband and I were in a debilitating boat accident eleven years ago, which was caused by hitting a submerged log in our path. He sustained a TBI, resulting in the removal of a large portion of his right temporal lobe. The injuries I sustained were all physical, resulting in the necessity of seven major surgeries since the accident occured. My husband was given a 5% chance of surviving the night after the accident and my injuries were not life-threatening, even though our lives changed drastically from that instant, and will never be close to life as we knew it prior to our tragic encounter that day, May 18, 2003.
We were both transported to different hospitals which was just the beginning of what would become our new “norm” many months and years later.
After 10 1/2 years of spending our time seeing doctors, undergoing constant testing, and necessary surgeries, we both seemed to just accept things as they were and never attempted to improve our lives. I think we both felt as though our lives as “contributing members of society” was over and we basically had nothing to look forward to, so each day that passed was a carbon copy of the day before, and we had no hope of things changing.
A dear friend of ours introduced us to a supplelment called EMPowerplus Q96. My husband was anxious to try the product thinking he had nothing to lose and could possibly experience good results from the product. He had nothing to lose.
I was a bit more skeptical and due to my chronic pain problems, I had become extremely depressed, spending weeks at a time in bed. I had no motivation to do anything!
After Neal, my spouse, tried the product and I noticed an immediate change in his daily routine which consisted of watching TV practically all day, falling asleep off and on. All of a sudden, he was outside pressure washing one side of the house which shocked me completely, it didn’t take me long to get to the kitchen and take one of the supplements, also. The next thing I knew I was washing clothes and completing tasks I had started days or weeks before, but didn’t have the energy or desire to complete them.


I love EMPowerplus! It’s expensive. I take 4 tabs a day, along with my pharmaceutical meds. I’m much higher functioning with it than without it. It IS expensive.


I have been using EMP for several months and have seen some positive effects but nothing wonderful. May end up going back on antidepressants but who knows. The EMP is quite expensive and they recommend taking aminos with it.

Jean Alkire

I first learned about Empowerplus from a Discover magazine article in about 2003. At the time I was oping with my daughter who was diagnosed with schizophrenia at a young age. She had been hospitalized regularly and suffered delusions only moderately regulated by antipsychotic medications. From the first day of taking Empowerplus, she was calmer and the voices were more manageable. Through six years of rehab, Empower plus helped her remain stable. Now, 10 years later, whenever she seems to relapse, we start her on this product. It’s expensive yes, but it’s been a godsend.


I can not say enough about this product to date. Life changing benefits being observed in my Adhd ,odd,ocd , anxiety,depressed child. Our relationship was strained as Parenting of a child with such needs is stressful to say the least. Nothing most likely will ever work for everyone but this has been a pivotal component for us. There is hope. Truehope!