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Symplex F Review – Is it Effective?

By Dr. Usmarah Hussain

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Synopsis | Ingredients | Is it Safe? | Warnings | Cost | Where to Buy? | Suggested Use | Bottom Line

Symplex F is a natural formula by a years-old renowned company that targets and improves women’s health. Enriched with photomorphogenic extracts from the bovine ovary, thyroid, pituitary, and adrenal glands, this blend can help women achieve and maintain a well-balanced hormonal system to improve their overall health and quality of life. With better hormonal working, well-managed stress levels, and high energy levels, women using Symplex F can expect to achieve a fuller, happier, and healthier life by simply adding a supplement to their daily routines.

This Symplex F review will discuss the supplement in detail, focusing on its key ingredients, benefits, costs, and the manufacturing company to help users decide if it is worth the time and effort.


1) Symplex F at a Glance

Women’s health has always been a key target of the supplements industry, given its crucial importance in everyday life. The intricate system of these naturally produced and maintained chemicals is essential to maintain functions vital for life, such as metabolism, stress management, and energy production. [1] Unfortunately, today’s fast-paced life is full of stressors and pollutants that quickly act on the body to induce hormonal imbalances, which, in turn, can lead to myriad problems for women.[2]

Symplex F by Standard Process was introduced to the world to help all such women fighting hormonal issues without any success. According to its manufacturing company, the core formula of this product provides uniquely derived nucleoprotein-mineral extracts that support cellular health. Furthermore, Symplex F combines the key ingredients from four other Standard Process dietary supplements: Thytrophin PMG, Ovatrophin PMG, Pituitrophin PMG, and Drenatrophin PMG.

2) The Company Behind Symplex F

Symplex F is manufactured by Standard Process, a family-owned, multi-generational nutritional supplement company founded by Dr. Royal Lee over 90 years ago. In 1926, Dr. Royal Lee realized the negative impact the average American diet had on general health. He acknowledged that processed foods were slowly depriving the human body of getting the nutrition it needed and deserved. With this concern in mind, Dr. Lee dedicated his entire life to developing a more advanced system for producing whole-food-based supplements.[3]

Decades later, Standard Process continues to work on Dr. Lee’s vision, sourcing its ingredients locally from certified organic farms. The company uses primary whole-food ingredients in manufacturing all dietary supplements, such as animal tissue extracts, botanicals, whole-food isolates, and concentrates. Out of the 300+ dietary supplements owned by the company today, some popular names are Congaplex – Whole Food RNA Supplement, Ligaplex II, Livaplex, Magnesium Lactate, ProSynbiotic, SP Complete, Catalyn, and Congaplex.



3) Details on Symplex F Ingredients and Uses

The main ingredient of Symplex F is a proprietary blend that combines different animal-based extracts. These extracts include the following ingredients:

  • Magnesium citrate
  • Bovine adrenal PMG extract
  • Bovine pituitary PMG extract
  • Bovine thyroid PMG extract
  • Bovine ovary PMG extract

Other ingredients include calcium stearate, calcium lactate, and cellulose.

4) Does Symplex F Work?

According to Standard Process, the Symplex F formula offers various benefits for women’s hormonal health owing to its proprietary blend. The blend consists of four bovine extracts primarily responsible for the majority of the benefits. Let’s look at these ingredients one by one to decide if Symplex F is likely to provide the benefits it claims

Bovine adrenal PMG extract

As suggested by the name, this extract contains extracts from the adrenal glands of animals. The adrenal glands are small glands located on top of each kidney and are responsible for producing four essential hormones: cortisol, aldosterone, adrenaline, and noradrenaline.[4] These four hormones are necessary for normal functioning in the body. They control many important functions[5], including:

  • Blood pressure
  • Metabolism
  • Sexual development before and during puberty
  • Salt and water balance
  • Blood sugar levels
  • Pregnancy
  • The balance of sex hormones, including testosterone and estrogen
  • Stress response

Hence, by taking this extract in the form of Symplex F, women are likely to achieve the benefits mentioned above.

Bovine thyroid PMG extract

By facilitating the building blocks needed for proper thyroid gland function, this PMG extract added to Symplex F can maintain thyroid gland function. Additionally, it maximizes the gland’s potential to break down all food types for energy production and increase the rate of protein synthesis in most tissues.[6]

Bovine ovary PMG extract

The unique Symplex F formulation can support healthy ovarian function. If the ovaries stop functioning normally in women, especially before age 40, it can lead to several health concerns.[7] Ovarian insufficiency occurs when ovaries don’t produce enough estrogen or release eggs regularly, leading to early infertility. Restoring estrogen levels in women with primary ovarian insufficiency can also help prevent complications occurring from low estrogen levels, such as osteoporosis.[8][9][10]

Bovine pituitary PMG extract

The pituitary gland is a small organ present in the brain, responsible for producing growth hormone, which maintains body tissues in adults and ensures adequate fat distribution. It also produces ACTH, a hormone that signals the body to respond to stress, impacting blood pressure and blood sugar levels. The pituitary gland also plays an essential role in cell division for growth and protein synthesis and oversees various metabolic activities involving the thyroid and adrenal gland function.[11][12][13]


In light of the ingredients discussed above, it becomes reasonably clear that Symplex F is very likely to provide the claimed benefits to its users.

5) Symplex F Benefits & Results

According to Standard Process, choosing Symplex F as a natural remedy to maintain and support hormonal health in women can be a wise choice because of the following key features the supplement possesses:

  • It is exclusively manufactured in the United States in a GMP facility
  • The composition is gluten-free
  • The product provides uniquely derived nucleoprotein-mineral extracts that support cellular health naturally without any side effects
  • It supports the healthy function of ovaries and the pituitary, adrenal, and thyroid glands for a well-balanced body
Is it Safe?

6) Symplex F – Is it Safe?

According to Standard Process, Symplex F is safe to use. However, some ingredients used in this formula are known to cause adverse effects in some users. A good example is magnesium citrate that even in lower amounts, may cause mild side effects such as:

  • Nausea
  • Electrolyte imbalance
  • Vomiting
  • Hypermagnesemia (increased magnesium levels in the blood)
  • Diarrhea
  • Abdominal cramping
  • Gas (flatulence)

However, in general, Symplex F has a good safety profile with no significant risks to health.


7) Symplex F Product Warnings

Adrenal extracts (from cows or pigs) have been used since 1900 to treat a wide array of medical conditions such as allergies, asthma, severe burns, morning sickness, or Addison’s disease. As better alternatives were developed, adrenal extracts (especially injectable ones) have mostly fallen out of use. Today, the only adrenal extracts available are in capsule or tablet form.

In 1989, the FDA (Food and Drug Administration) banned all imported adrenal extracts. Subsequently, in 1996, the organization also recalled injectable extracts. [14] The FDA also released public alerts warning against the use of such extracts after reports suggested that more than 50 people contracted infections from contaminated products. Hence, it is imperative to be mindful of any infectious symptoms while using Symplex F. [15]

Where to Buy?

8) Where to Buy Symplex F

Because all Standard Process products are available through consultations with qualified practitioners, Symplex F is only available in several online stores like NHC and eBay. The complete list of sellers having this product in stock is available on the company’s official website (standardprocess.com).


9) How Much Does Symplex F Cost?

Symplex F comes in two different packaging containing a different number of pills. A pack of 90 pills is available for $21.45, whereas a pack of 360 pills costs $77. Remember that the prices may vary depending on where a person buys the product from. In general, Symplex F seems like an affordable purchase to add to daily life.

Suggested Use

10) Suggested Use

Symplex F recommended dose is one (1) tablet per meal or as directed by a medical professional.

11) What the Customer Symplex F Reviews Say

"I have been taking this product for 5 years. An acupuncturist prescribed it for me for hot flashes. I started with 1 three times a day and gradually reduced it to 1 tablet a day. It definitely lessened the hot flash intensity and frequency." [Read full review]


"I used this product after I consulted with a physician about my hormone imbalance to improve my health. I recommend using this product if you are trying to get healthy & balance your hormones." [Read full review]


"The tablets Symplex F has put my mood swings back to order. I feel great. I take them 3 times a day and my life has changed! I became more active, and my anxiety is just gone! Please restock them!" [Read full review]


Bottom Line

12) Our Bottom Line

Symplex F claims to provide an easy solution to women fighting hormonal issues. The supplement includes bovine extracts that target four key hormonal systems in the body at once, including the adrenal, thyroid, ovaries, and pituitary glands. Despite the limited user testimonials primarily because of the limitations of selling the product online, the ones available are generally positive. In terms of price, Symplex F is a bit more affordable compared to other similar dietary products.

However, one of the issues with this product is its proprietary blend of bovine PMG extracts. Because all four PMG extracts are part of the proprietary blend, there’s no way to know how much of each extract a person can get per serving. Overall, Symplex F seems to support female health, as advertised. Still, caution is recommended when choosing a product based on animal gland extracts.

3.9/5 - (55 votes)

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I have tried to take this product a number of times and find I start feeling anxious. I’m wondering if it maybe the adrenal extract kicking in? Anyway, when I stop taking it, the anxiety vanishes, so not a good product for me.

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Anxiety Increases
Have you tried this product?

Does it mess with your cycles? And yes it Definetly is great product ! I had extreme ptsd and anxiety and after a month it stopped really happy with it been taking it for 6 months now

Title for your comment
Love it !
Have you tried this product?

This has calmed anxiety for me, so wondered if I was really having adrenal or thyroid problems. Will continue with this, I am impressed. Have not found anything to help.

Mary J

I have both thyroid and adrenal dysfunctions and this formula helps me with both problems and in an effective way!


Normally I don’t use products that have animal ingredients, but I heard good things about this one and decided to give it a try, I am very pleased with this decision and my thyroid health is back to normal.

Brian and barbara Jolley

Since I have been taking this I have been gaining weight I’ve been trying to find side effects and cannot I exercise everyday wondering if you can answer my question on that I wondered if it is this pill simplex f


I do believe you gain a little bit weight and your breasts get larger too. I usually drink lots of water with lemon and apple cider vinegar’. I don’t have problems with overweight, but I definitely can get 4-6 lb extra, the max