Home » Reviews » Other » Symplex F Review

Symplex F Review – Is it Effective?

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Synopsis | Ingredients | Claims | Is it Safe? | Warnings | Cost | Shop For Symplex F | Suggested Use | Bottom Line

Symplex F is a combination formula for women’s health containing Protomorphogen extracts from bovine ovary, thyroid, pituitary, and adrenal glands.

This supplement is made by Standard Process, a family-owned business founded in 1926 by Dr. Royal Lee. It’s the same company behind Cataplex B.


1) Symplex F at a Glance

According to Standard Process, Symplex F was developed to provide unique derived nucleoprotein-mineral extracts that may support cells’ health.[1]

Furthermore, Symplex F contains a combination of key ingredients from four other Standard Process dietary supplements: Thytrophin PMG Ovatrophin PMG, Pituitrophin PMG, and Drenatrophin PMG.

Typically, adrenal extracts (such as those available in Symplex F) are used for fatigue, low adrenal function, asthma, lowered resistance to illness, stress, severe allergies, rheumatoid arthritis, and certain skin conditions such as eczema and psoriasis.[2]

2) The Company Behind Symplex F

Standard Process is a family-owned, multi-generational, and operated nutritional supplement company founded by Dr. Royal Lee over 90 years ago.

In 1926, Dr. Royal Lee understood the negative impact the average American diet had on general health. He acknowledged that processed foods exhausted our food sources of rich nutrition once found in them. Dr. Lee dedicated his entire life to developing a more advanced system for producing whole-food-based supplements.[3]

Even today, Standard Process sources its ingredients locally from certified organic farms. The company uses primary whole food ingredients in the manufacturing process of various dietary supplements containing whole food extracts, animal tissue extracts, botanicals, whole food isolates, and concentrates.

Out of the 300+ Standard Process dietary supplements, some popular names are Congaplex – Whole Food RNA Supplement, Ligaplex II, Livaplex, Magnesium Lactate, ProSynbiotic, SP Complete, Catalyn, and Congaplex.

How to contact the Standard Process company:

  • Website: standardprocess.com
  • Phone: 800-558-8740
  • Fax: 800-438-3799
  • Headquarters: 1200 W. Royal Lee Drive, Palmyra, WI 53156
  • Email: info@standardprocess.com


3) Details on Symplex F Ingredients and Uses

Symplex F includes the following active ingredients:

  • Proprietary Blend (Magnesium citrate, bovine adrenal PMG extract, bovine pituitary PMG extract, bovine thyroid PMG extract, and bovine ovary PMG extract) 135 mg.
  • Calcium 20 mg

Other ingredients include calcium stearate, calcium lactate, and cellulose.

4) Does Symplex F Work?

According to Standard Process, the Symplex F formula offers four essential benefits:

1) Supports the healthy functioning of the adrenal glands

The adrenal glands are small glands located on top of each kidney. They are responsible for producing four essential hormones: cortisol, aldosterone, adrenaline, and noradrenaline.[4]

These four hormones are necessary for normal functioning in the body. They control many important functions[5], including:

  • Blood pressure
  • Metabolism
  • Sexual development before and during puberty
  • Salt and water balance
  • Blood sugar levels
  • Pregnancy
  • The balance of sex hormones, including testosterone and estrogen
  • Stress response

2) Promotes healthy thyroid function

By facilitating the building blocks needed for proper thyroid gland function, Symplex F may maintain the thyroid gland’s capacity to maximize the potential of all food types for energy production and increase the protein synthesis rate in most tissues.[6]

3) Supports healthy ovarian function

The unique Symplex F formulation may support healthy ovarian function. If the ovaries stop functioning normally, especially before age 40, it can lead to several health concerns.

When ovarian insufficiency occurs,[7] the ovaries don’t produce enough estrogen or release eggs regularly. This condition may lead to infertility. Restoring estrogen levels in women with primary ovarian insufficiency helps prevent complications occurring from low estrogen levels, such as osteoporosis.[8][9]

Symptoms and signs of primary ovarian insufficiency[10] are similar to those of estrogen deficiency or menopause and include:


  • Hot flashes
  • Irregular or skipped periods
  • Night sweats
  • Difficulty getting pregnant
  • Irritability or difficulty concentrating
  • Dry eyes

4) Supports healthy pituitary function

The pituitary gland produces growth hormone, which maintains body tissues in adults and distributes fat. It also produces ACTH (a hormone that signals the body to respond to stress, impacting blood pressure and blood sugar levels), which causes cortisol release from the adrenal gland.

The pituitary gland plays an essential role in cell division for growth and protein synthesis and oversees a number of metabolic activities involving thyroid and adrenal gland function.[11][12][13]


5) Symplex F Claims

Symplex F claimed benefits include:

  • Supports the healthy function of ovaries and the pituitary, adrenal, and thyroid glands;
  • Made in the United States in a GMP facility;
  • Gluten-Free.
  • Provides uniquely derived nucleoprotein-mineral extracts that support cellular health;
Is it Safe?

6) Symplex F – Is it Safe?

According to Standard Process, Symplex F is safe to use. However, some ingredients used in this formula are known for causing adverse effects in some users. A good example is magnesium citrate that even in lower amounts may cause mild side effects such as:

  • Nausea
  • Electrolyte imbalance
  • Vomiting
  • Hypermagnesemia (increased magnesium levels in the blood)
  • Diarrhea
  • Abdominal cramping
  • Gas (flatulence)

7) Symplex F Product Warnings

Adrenal extracts (from cows or pigs) have been used since 1900 to treat a wide array of medical conditions such as allergies, asthma, severe burns, morning sickness, or Addison’s disease.

As better alternatives were developed, adrenal extracts (especially injectable ones) have mostly fallen out of use. Today, the only adrenal extracts available are in capsule or tablet form.

In 1989, the FDA (Food and Drug Administration) banned all imported adrenal extracts. Subsequently, in 1996, the FDA recalled injectable extracts too.[14]

The FDA also released public alerts warning against the use of such extracts after reports suggested that more than 50 people contracted infections from contaminated products.[15]

Shop For Symplex F

8) Who Sells Symplex F?

Because all Standard Process products are available through consultations with qualified practitioners, Symplex F is only available in several online stores like NHC and eBay, as well as in some local stores or from health professionals from your area.


9) How Much Does Symplex F Cost?

One bottle of Symplex F (360 capsules / 120 servings) costs around $74, but the price may greatly vary from one retailer to another. On top of that, your buying options are pretty limited, most stores allowing only one bottle per order.

Suggested Use

10) Suggested Use

Symplex F recommended dose is one (1) tablet per meal or as directed by a medical professional.

11) What the Customer Symplex F Reviews Say

"I have been taking this product for 5 years. An acupuncturist prescribed it for me for hot flashes. I started with 1 three times a day and gradually reduced it to 1 tablet a day. It definitely lessened the hot flash intensity and frequency." [Read full review]


"I used this product after I consulted with a physician about my hormone imbalance to improve my health. I recommend using this product if you are trying to get healthy & balance your hormones." [Read full review]


"The tablets Symplex F has put my mood swings back to order. I feel great. I take them 3 times a day and my life has changed! I became more active, and my anxiety is just gone! Please restock them!" [Read full review]


Bottom Line

12) Our Bottom Line

One thing that works in Symplex F’s favor is how popular this product actually is. Even though there aren’t that many user testimonials (primarily because of the limitations of selling the product online), the ones we could find were generally positive.

Regarding price, Symplex F is a bit more affordable compared to other similar dietary products.

However, one of the issues we have with this product is the proprietary blend of bovine PMG extracts. Because all four PMG extracts are part of the proprietary blend, there’s no way of knowing how much of each extract you can actually get per serving.

Overall, Symplex F may support female health, as advertised. Still, we recommend caution when choosing a product based on animal gland extracts. Consult your healthcare provider. He or she could suggest better alternatives or work with you at creating a personalized treatment scheme.

4/5 - (32 votes)

Reference Sources

Inline Feedbacks
View all comments

I have tried to take this product a number of times and find I start feeling anxious. I’m wondering if it maybe the adrenal extract kicking in? Anyway, when I stop taking it, the anxiety vanishes, so not a good product for me.

Title for your comment
Anxiety Increases
Have you tried this product?

Does it mess with your cycles? And yes it Definetly is great product ! I had extreme ptsd and anxiety and after a month it stopped really happy with it been taking it for 6 months now

Title for your comment
Love it !
Have you tried this product?

This has calmed anxiety for me, so wondered if I was really having adrenal or thyroid problems. Will continue with this, I am impressed. Have not found anything to help.

Mary J

I have both thyroid and adrenal dysfunctions and this formula helps me with both problems and in an effective way!


Normally I don’t use products that have animal ingredients, but I heard good things about this one and decided to give it a try, I am very pleased with this decision and my thyroid health is back to normal.

Brian and barbara Jolley

Since I have been taking this I have been gaining weight I’ve been trying to find side effects and cannot I exercise everyday wondering if you can answer my question on that I wondered if it is this pill simplex f


I do believe you gain a little bit weight and your breasts get larger too. I usually drink lots of water with lemon and apple cider vinegar’. I don’t have problems with overweight, but I definitely can get 4-6 lb extra, the max