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St. John’s Wort with Folate and B12 Review – 8 Essential Things to Know

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Summary | Nutrition Facts | Claims | Warnings | Price | Suggested Use | Verdict

St. John’s Wort with Folate and B12 is presented to be a dietary supplement that was designed to support mood.

The manufacturer is called Metagenics and is a United States business that is privately owned and was established in 1983 in California, now having an international status with offices in countries like Belgium, the Netherlands, Canada, Australia, and New Zealand. At this moment this business owns 43 active patent blends and has more then 230 others pending. Research in nutrigenetics is conducted as to find ways of bettering their product and to also manufacture new more effective ones, nutrigenetics being the science that studies the effects that different nutrients have on the genetic expression within cells.

St. John’s Wort with Folate and B12 has been manufactured in order to support a calm and positive mood and it is also said to sustain a healthy mental state as well. This formula contains nutrients that have an active role in the synthesis of serotonin in the body, thus being effective in regulating sleep and can also help with learning and memory. St. John’s Wort with Folate and B12 contains no ingredients that come from an animal source and thus is vegetarian-friendly.

Summary

1) What is St. John’s Wort with Folate and B12?

St. John’s Wort with Folate and B12 is a multi-vitamin blend of ingredients that combines a herbal extracts with a B-vitamin complex.

Folate is one of the active ingredients that are used in this blend and is a B vitamin that is commonly found in leafy vegetables, okra, fruits, asparagus, mushrooms, or beans. The body requires proper levels of this substance, as a lack of can lead to anemia or the inability of the bowels to properly absorb nutrients. This ingredient has been used with success with conditions like Alzheimer’s disease, nerve pain, muscle pain, heart disease, or vitiligo. Low levels of this vitamin have been observed in patients that suffer from depression and some studies indicated it can be effective in treating anxiety and depression. High doses of this vitamin can lead to side effect like diarrhea, abdominal cramps, sleep disorders, irritability, or confusion.

Vitamin B12 is another active principle and is an ingredient that has been found to produce brain chemicals that help with mood management and also sustain other brain functions. There also are studies that observed a low level of this vitamin in people that are suffering from depression.

Nutrition Facts

2) St. John’s Wort with Folate and B12 Nutrition Facts

St. John’s Wort with Folate and B12 contains the following ingredients: Folate, Vitamin B12, St. John’s Wort Aerial Parts, Microcrystalline cellulose, croscarmellose sodium, silica, stearic acid (vegetable), and coating (water, hypromellose, medium chain triglycerides, and hydroxypropylcellulose).

3) Does St. John’s Wort with Folate and B12 Work?

This blend of ingredients falls in the category of multi-vitamin formulas and is made using vitamins and herbs.

One of the B vitamins that play an active role in this blend is called Folate and can be found in foods like leafy vegetables, asparagus, okra, fruits, mushrooms, beans, or yeast. Low levels of this substance in the body can lead to complications like anemia or the inability of the bowel to properly absorb nutrients. This ingredient can help with some general health issues as well, such as Alzheimer’s disease, nerve pain, muscle pain, vitiligo, or heart disease. In patients that suffer from depression, there have been observed low levels of Folate, some studies have indicated that this vitamin can help with anxiety as well as depression and can also sustain brain health as well. If used in high doses this ingredient may cause side effects like abdominal cramps, diarrhea, sleep disorders, confusion, irritability, or stomach upset.

Vitamin B12 is also an active ingredient that can be found in this product and is a substance that has been found to produce brain chemicals that affect mood as well as other brain functions. As with Folate, low levels of this vitamin have also been observed in people that suffer from depression.

The suggested use is to take one tablet, twice a day between meals.

The manufacturer states that pregnant or nursing women are not to use this product as well as people that are planning on having surgery. If using any medication, the manufacturer recommends a medical consult before any use.

Claims

4) St. John’s Wort with Folate and B12 Claims

  • This product does not only influence mood, but sustains brain health as well.
  • Each container provides a one-month supply of formula.
  • No animal source ingredients are present in this blend and, thus, is vegetarian-friendly.

Warnings

5) St. John’s Wort with Folate and B12 Product Warnings

  • The price is high, about $45 for a one-month supply.
  • There are no relevant online testimonials about this product.
  • Pregnant or nursing women are warned not to use this product.

Price

6) St. John’s Wort with Folate and B12 Price

This product comes at a high price, and each container provides 60 tablets and a one-month supply, at the recommended dosage of two tablets per day. This product can be purchased in many cases directly from a health care practitioner or directly from the manufacturer’s website with a code, which can be obtained from a medical doctor that has a partnership with this company, several online retailers also present this formula as well. Without the practitioner code the shipping prices are not made available, and there also are no mentions of a free trial program or money back guarantee.

Suggested Use

7) Suggested Use

This product comes in a container that holds 60 tables and provides a one-month supply at the suggested use of two tablets per day.

Verdict

8) Our Verdict on St. John’s Wort with Folate and B12

St. John’s Wort with Folate and B12 is a dietary health product that presents with mood enhancing properties and also provides some positive effects that support brain health. The ingredients chosen are well known and have been extensively studied, offering effects that help with conditions like Alzheimer’s disease, nerve pain, or heart disease. Every container of formula holds 60 tablets and is designed to last a month, coming with a high price and with no free trials or money-back guarantees. This product is suitable for vegetarian use, but nursing or pregnant women are not to use it.

4/5 - (2 votes)
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Twentry

I feel some mood changes, but not anything life changing.

J. Gardner

Most other B vitamin based formulas don’t carry a punch like this one, this blend started showing effects just three days after a started taking it.