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Phosphatidylethanolamine Review – 4 Reasons Why

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Ingredients | Price | Verdict

Phosphatidylethanolamine (also known as cephalin and abbreviated PE) is a lipid found in biological membranes. Its role is to support the transmission of information through the brain.
Many manufacturers are using this substance in their products. PE may appear alone or combined with other ingredients. It is important when choosing a PE-based supplement to read the ingredients carefully. For instance, some formulas may combine top quality ingredients, while other may not. The amount of milligrams for a daily dose also affects the value.
Phosphatidylethanolamine is a complex substance. Consumers are advised to evaluate brand names, return or money-back guarantee policies, ingredients and the overall formula before making a purchase.


1) Phosphatidylethanolamine Ingredients

Not Applicable

2) Does Phosphatidylethanolamine Work?

Phosphatidylethanolamine is a type of Phospholipid that is found in plants and animals. Studies show that approximately 45% of the lipids in the brain and 20% of those in the liver are the result of it, so it does play a crucial role for overall health benefits.

While this substance is still under clinical research, scientists believe that a high amount of Phosphatidylethanolamine may induce calm, relaxation and an overall improvement in the cognitive function. Reducing fatigue is also a possible benefit.

We need to point out once again that this ingredient is used by various manufacturers in their products. It may appear alone or combined with other ingredients. Therefore, the recommended dosage will vary from one supplement to another.

Phosphatidylethanolamine is not particularly dangerous, but patients with health problems, those who are taking prescription medication and pregnant or nursing women should avoid this substance.


3) Phosphatidylethanolamine Price

The cost of Phosphatidylethanolamine supplements will vary based on the formulation you choose. It is advised to compare the value of the brand and the recommended daily dosage. Take the total number of capsules and divide by the number you are supposed to take every day. That will offer you the overall price per capsule.

Phosphatidylethanolamine-based supplements are quite popular. You should be able to purchase them from online retailers or local retailers. If you choose to buy the product online, please take into consideration the shipping costs as well.


4) Our Verdict on Phosphatidylethanolamine

The evidence we have shows that Phosphatidylethanolamine is effective in treating the symptoms associated with stress, depression; as well as improving the overall well-being.

However, many manufacturers are offering this substance along with other ingredients, all combined in a more complex formula. Therefore, it is important to further research into such formulations.

4/5 - (1 vote)
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Used a supplement containing cephalin and it actually worked, but couldn’t find it anymore. Still looking, so if anyone knows please leave a comment.