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Parnate Review – 4 Essential Things to Know

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | What's Inside? | Cost | Bottom Line

Parnate (also known as Tranylcypromine Sulfate) is a form of antidepressant medication available only by prescription. The company that produces this drug is Glaxo SmithKline. They are located in Wales, United Kingdom.

This form of a prescription drug is recommended to treat patients with major depressive disorder. This medication is to be taken as a form of treatment for long-term depression that hasn’t responded to other treatment types.

Please note that Parnate is a form of prescription medication, and it should not be purchased or used without your doctor’s consent. Do not buy this product from questionable sources.

What’s Inside?

1) What’s Inside Parnate?

Parnate includes the following ingredients: tranylcypromine sulfate, cellulose, citric acid, croscarmellose sodium, D&C Red No. 7, FD&C Blue No. 2, FD&C Red No. 40, FD&C Yellow No. 6, gelatin, lactose, magnesium stearate, talc, titanium dioxide, and trace amounts of other inactive ingredients.

2) Is Parnate Right for You?

Parnate is advertised as a potent form of antidepressant recommended as a last resort treatment when everything else has failed to show results.

This is a potent form of medication. It should only be used under the close supervision of a doctor. This type of medicines (better known as MAOI- Monoamine Oxidase Inhibitor) should never be discontinued without a physician’s consent.

Doing such may lead to withdrawal symptoms, including tremors, body temperature changes, and nausea.

Parnate is believed to work by increasing various chemicals (serotonin, norepinephrine, and epinephrine) and elements in the brain.

There is little information on this product. However, some studies suggest that increasing the chemical production of serotonin can help to balance mood. It is important to note that this aspect is still under research, and the preliminary results may be inconclusive.

This drug has been associated with numerous side effects, including nausea, vomiting, irritability, insomnia, blurred vision, ringing in the ears, and heartbeat changes.

This product should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have:

  • a certain kind of adrenal gland tumor (pheochromocytoma);
  • cerebrovascular disease (e.g., stroke);
  • heart problems (e.g., congestive heart failure, heart attack);
  • high blood pressure;
  • history of severe/frequent headaches;
  • liver problems.

3) How Much Does Parnate Cost?

Parnate is an expensive form of medication. Since this medication can be dangerous, possible treatment will only start with the smallest possible dose. Some doctors may offer free samples of Parnate to see how a patient will react to the medication.

If you cannot afford to pay for the treatment, it is recommended to consult with your doctor. He may be able to suggest alternative therapies.

Bottom Line

4) The Bottom Line – “Does it Work?”

Parnate has received many positive reviews and testimonials, and it enjoys a good rating on specialized websites and forums. However, as it is a form of prescription medication, it cannot be obtained without a doctor’s written consent.

We strongly recommend consulting with your physician or pharmacist before taking this product.

4/5 - (5 votes)
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