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Moclobemide or Manerix Review – 8 Facts You Need to Know

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Facts | Ingredients | Claims | Cautions | Price | Suggested Use | Conclusion

Moclobemide or Manerix is a form of prescription medication used in the treatment of various forms of depression. Depression is a condition that more and more people suffer from, due to stress, lack of rest, and an unhealthy lifestyle. While treating it in its incipient phases is easy to do, leaving it untreated can have very harmful effects, suicide and tendencies to harm other being two of the possible consequences of an untreated case of depression.

There are many companies that commercialize Moclobemide or Manerix, one of which is Roche, one of the largest pharmaceutical companies in the world. Founded in 1896, the company had a slow and steady ascent towards being one of the most successful companies that deal with health supplements and prescription medication.


1) Moclobemide or Manerix Quick Facts

The active ingredient of Moclobemide is used in many formulations, all of them dealing with various forms of depression or anxiety. The substance is not yet approved in the US, but has been successfully used in Europe and Asia in treatment of psychotic depression, bipolar depression, neurotic depression, social anxiety, and many other similar ailments.

The list of counter indications for this substance is quite extensive, as interactions with other forms of medication, or already present conditions can prove dangerous. It is not advised to take full doses if you suffer from liver failure, hyperthyroidism, and caution is recommended in people taking serotonin-based medication, or suffering from hypertension.


2) Details on Moclobemide or Manerix Ingredients and Uses

Moclobemide or Manerix contains: Moclobemide.

3) Does Moclobemide or Manerix Work and it is Safe?

Moclobemide or Manerix is known as a MAOI which stands for Monoamine Oxidase. It is stated to work by preventing the various types of chemicals in the brain that can cause depression from getting to the nervous system. This can be a very complex process because each can have a different type of chemical makeup. It can be tough to determine how much of the chemicals are in place and therefore how much of the medication needs to be used to block them successfully.

The medication may need to be used for several weeks before someone starts to notice that they feel better. This information is based on various clinical studies that have been done involving adults. There is no information at this time about testing on those under 18. As a result, Moclobemide or Manerix isn’t prescribed for those under 18 years of age.

Moclobemide or Manerix may cause a problem for anyone who is taking other forms of prescription medications. Disclosing them to the doctor is critical. The use of alcohol or tobacco products can also make the problems with side effects worse from this medication. Individuals that have been diagnosed with hypertension or liver problems shouldn’t use this medicine.


4) Moclobemide or Manerix Claims

  • Intensively researched product;
  • Manufacturer is ranked among the top producers of pharmaceutic products worldwide;
  • Contains no added stimulants or caffeine;
  • Product claims are supported by large amounts of clinical tests and trials;

5) What You Need to Know Before Taking Moclobemide or Manerix

  • Product is only available via prescription;
  • Large list of possible side effects and counter indications;
  • Caution is advised for people suffering from liver or thyroid gland dysfunctions;
  • Active ingredient is not yet approved in the United States;

6) Moclobemide or Manerix Price

The cost of Moclobemide or Manerix mostly depends on the brand name. The generic versions of medications typically will offer the same benefits, though. Individuals that have prescription plan coverage or health insurance should be able to get the product included.

A person needs to check out the specific guidelines of their coverage to see what is included. There could be a co-pay or deductible that also applies each time that the medication has to be refilled at the pharmacy.

Suggested Use

7) Suggested Use

The product is considered safe for elderly, provided they do not suffer from any of the conditions listed as dangerous and are not taking any other forms of medication. The recommended dose varies from person to person, and is usually decided by the doctor prescribing it. Usage by people under the age of 18 is strongly discouraged, as well as taking Moclobemide if it wasn’t prescribed to you.


8) Conclusion

Dealing with depression can prove very difficult, this being a condition that requires some changes in lifestyle and mentality. If you suffer from depression, finding the right medication is essential, and can make the difference between leading a normal healthy lifestyle and experiencing a downwards spiral. It is, therefore, very important to contact your doctor as soon as you notice any symptoms of depression, in order to begin treatment as soon as possible.

There is no question whether Moclobemide or Manerix works or not, it being a fully-tested, prescription-only medication. What is left to be discerned is whether it’s the right choice for you, but that question can only be answered by your doctor.

3.4/5 - (12 votes)
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I was on it for 6 months, and while it helped my mood, energy, etc a lot, It also raised my blood preasure and gave me nonstop headaches and migraines at the higher dose. I was at 750mg though, at lower doses it didn’t do much for me.


I tried this for a few weeks and did have a few positive experiences at the beginning (mainly increased concentration and social communication), although near the two week mark I started to get increasingly agitated and almost agoraphobic as I didn’t want to be in public (much like Pristiq did). I have since discontinued but wondered if it gets better longer term (although I hear that the dose needs to keep being raised).