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Deplin Review – Is it Effective?

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Overview | Formula | Claims | Precautions | Cost | How To Take | Conclusion

Deplin is a prescription drug recommended as an antidepressant and antipsychotic. The drug is produced by Pamlab, a biomedical company specialized in developing natural medicine of the highest quality. The company claims to provide personalized solutions that safely approach distinct nutritional requirements for people suffering from various health concerns. Their particular interest in studying metabolic imbalances and the genomic factors that affect certain types of people is what distinguishes them from competition.

The formula is marketed as a prescription vitamin based on the active form of a naturally occurring substance in the human body called Folate. This form is known as L-methylfolate and is an essential substance for the formation of healthy DNA and prevention of DNA damage. Deplin is prescribed to treat different conditions caused by a deficiency in this vitamin including low plasma and low blood cell folate, and other conditions such as mood related disorders. L-methylfolate is included in the trimonoamine modulators category of antidepressants and is particularly needed by the body for proper synthesis of important neurotransmitters like Serotonin, Norepinephrine and Dopamine, substances known to affect the sense of well-being and the body’s response to stress. Among the advertised benefits, the manufacturer mentions increased alertness, mood, and concentration, enhanced ability to take initiative, motivation, and increased sociability.

The formula is recommended only to adults. Official information can be achieved after completing the form available on the manufacturer’s webpage.


1) Quick Overview

Deplin is based on a single active ingredient, the natural form of Folic acid known as L-methylfolate. This is claimed as the only form to cross the brain blood barrier, which makes the product effective in regulating levels of important neurotransmitters associated with mood. The active substance is claimed to be a medical food, which is different from both dietary foods and drugs. The compound is known to be used in the normal formation of genetic material, particularly helpful in the case of fetuses for the prevention of DNA mutations such as neural tube defects. Another important function is in the synthesis of the neurotransmitters Serotonin, Norepinephrine, and Dopamine. Serotonin is known to particularly influence the sense of well-being and happiness, regulate mood, appetite, and sleep, and improve memory and learning skills. Dopamine is vital for neural transmission and is particularly linked to memory related skills and motivational actions.

Norepinephrine is an excitatory neurotransmitter also linked with mood regulation. Imbalance in this substance has been shown to result in increased anxiety, sleeping problems, decreased focus and low energy.Adequate levels of Folate are considered highly important for mental and cognitive health and maintenance of proper levels of nutrients in the brain. Reduced Folic acid levels may also lead to cardiovascular problems (including blood clots) and schizophrenia symptoms.

Deplin medication is not recommended for pregnant, planning to become pregnant or breast-feeding women, patients who are under any other treatment, people with known allergies or low levels of vitamin B9. Drug interactions have also been reported, including with non-steroidal anti-inflammatory drugs, barbiturates, and other drugs. A full list of interactions can be provided by a specialized healthcare practitioner. The most common Deplin side effects are allergic reactions with symptoms like rash and itching, difficulty breathing, swelling of the mouth, lips, face or tongue, and tightness in the chest.


2) What Are Deplin Ingredients?

Deplin contains the following ingredients: Silicified Microcrystalline Cellulose, Algae-S Powder (Schizochytrium Algal Oil), Glucose Syrup Solids,
Mannitol, Sodium Caseinate (milk), Soy Protein, High Oleic Sunflower Oil, 2% or less Sodium Ascorbate, Tricalcium Phosphate, Tetrasodium Diphosphate, Natural Flavors, Soy Lecithin, and Mixed Natural Tocopherols and Ascorbyl Palmitate), Gelatin (Kosher Ko), L-methylfolate Calcium, Magnesium Stearate Vegetable Source), Titanium dioxide(color), FD&C Yellow #6(color), FD&C Red #40(color), Propylene Glycol, and Povidone.


3) Deplin Claims

  • The formula is manufactured by a reputable producer
  • The active ingredient is able to cross the blood-brain barrier
  • A large number of consumers support the formula’s effectiveness in treating symptoms of severe depression and other mood related disorders
  • The formula has been clinically studied
  • Deplin’s active ingredient is the natural form of folic acid

4) Precautions of Deplin Use

  • The formula is not recommended without the prior consent of a healthcare specialist
  • Potentially dangerous drug interactions and Deplin side-effects are possible (immediate medical attention is recommended in these cases)
  • Deplin cost for a month supply is high
  • Deplin ingredients may cause allergic reactions (special precaution is advised for individuals with known allergies to any of these substances)

5) How Much Does Deplin Cost?

Deplin’s price will vary based on concentration (7.5 mg or 15 mg). Regardless of the strength, Deplin is very expensive, and it is available for purchase with prescription only. While there are no online retailers for this product, there are several websites offering coupons and discounts for those who buy Deplin from their partners.

It is very likely that some patients will not be able to afford the cost of the treatment. In this case, we recommend you to address the issue to your doctor. He may be able to come up with some alternative treatments to replace Deplin.

Please take into consideration that this product is recommended for severe depression only. If you are diagnosed with mild to moderate depression, anxiety or panic attacks, you should focus on more proper treatments.

If you prefer a more cost-effective nootropic, check out Puridian Brainalin . One bottle is not more than $30.00.

How To Take

6) How to Take Deplin

Deplin dosage varies depending on the condition and should be recommended by a healthcare specialist.


7) Conclusion

The answer to the question “What is Deplin” and how it works is complex. Deplin is a formulation based on the therapeutic action of a bio-available form of the vitamin B9. The formula is offered as an additional support for those who are on antidepressants, suffer from schizophrenia or are unable to convert dietary foliate into L-methylfolate. The formula is advertised as a natural sourced product that has a major advantage to synthetic-based dietary supplements and formulations: that of crossing the BBB. Deplin for depression is very popular among users of antidepressants and is claimed to have helped patients who have been struggling for years with severe depression symptoms and other conditions. Clinical trials have shown that the combination of Deplin medication with SSRI drugs was effective in considerably lowering symptoms of major depressive disorder as compared to placebo drugs.

Deplin is not indicated for several categories of people including those with hypersensitivity to any of the ingredients listed. Moreover, given all the potential dangers that may occur in case of incorrect administration or any specific health issues of each consumer, it is highly recommended not to use this formula unless a doctor has given its consent and only in the recommended doses.

3.5/5 - (19 votes)
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Pamela T.

The doctor prescribed this drug because I was having numerous anxiety attacks. Besides that I had mood swings, was emotionally unbalanced and just could not get out of that state, no matter what I did. I was diagnosed with depression and immediately started the treatment. I must say, this product has helped me to feel more relaxed and see things differently. My depression has considerably decreased, although I sometimes feel sad without any reason. But compared to what I was a few months back, now I feel like a totally different person. I am starting to enjoy and appreciate little things and I think I am on the right way.

Michael M.

This drug was a life savior for me. I started taking it after a severe depression which started after I lost my wife. I could not sleep at night and I was having a lot of suicidal thoughts. The doctor prescribed it to me after trying various other antidepressants. But this one was effective immediately. Now, after almost a year I am able to function normally, I sleep all through the night, and I don’t feel sad all the time.

Richard Arlus Williams-Obanion

This was suposedly perscribed due to a DNA test where my results were shared with the sales department of the so called vitamin. I am alergic to any form of antidepressant and have been tricked in the past by Doctors that assume because I suffer from chronic pain I must be depressed when this is not the case.
I caused depression, extreme bloating, anxiety, cracked my sternum bone and ribs during the bloating. When I stoped taking this my Doctor fired me without throughly investigating how this magic lump apeared and I felt like my ribs were broken. Swept under the rug is what they call it. It took the company almost a year to take this seriously.

Liz Zamora

In addition to antidepressants, I been taking Deplin for several months now. I haven’t done much for many years, but I’m definitely doing more now than I used to do. I feel focused, I have the desire to do things and go places. As I said, I don’ t do too much, but at least I want to do things and go places. This is the newest Rx I received from my doctor, so I know it’s what has made a difference in how I feel and think. Thank you very much for helping me take a big step forward toward normal.


I’ve been taking Zoloft for a couple years now and Trazodone about a year now. I still have trouble with depression and anxiety so my psychiatrist suggested I try this for a month and see how I am with this on top of my regular pills. Any concerns about this pill I should be aware of?


I’ve taken Deplin for about two yrs. I wasn’t able to take antidepressants because of stomach issues, found out about Deplin and I will never discontinue taking it. It has helped me SO MUCH and there are no side effects, just better mood!!

mike g
Reply to  Susan

miracle product for me. took away depression and migraines.


I just started taking deplin. I have great hope it will help me to feel better


Just had this product shipped today. I took the genetic test and the results showed that I struggle with processing folate. Hoping it will help my MDD. Cross your fingers for me!


Dr prescribed it after some genetics test and after about two weeks I realize that I didn’t have a cloud over my head anymore. I decided to go off of it of course just to make sure and after 2 weeks the symptoms came back on big time. I shoulda never went off the medicine and I’m so glad that it’s available. My only regret is I didn’t know about it sooner.

Marcelinho lopez

I love Deplin I have suffered from severe anxiety and panic attacks for years. I recently found out I have the MTHFR mutation and was recommended to me by my naturopathic doctor. I have been taking it by its self 15 mg and I have less anxiety and panic attacks even under alot of stress. I’m sleeping better as well. I tried taking every daily out there not for me it made me so sick every time. Get the genetic test done it was really helpful for me.


I think it does help me. I have major depression, GAD and panic attacks. It has many other fillers in it and the price to me is definitely the worst thing about it to me. Almost $100 a month. Gimme a break. After using the samples I got from my psychiatrist I looked for a cheaper version which also is cleaner. Made by Matabolic maintenance is called methyl pro

Terri Ann
Reply to  Joshua

Hi Joshua, I had the same issue with paying $85 out of pocket for Deplin however, my pharmacist at Rite-Aid went on line and found me a discount. Now I only pay $40 a month! So I would suggest you ask your pharmacist to go on line and find discount or you. I have gone off Deplin to test if it was helpful and with in a couple days the depression and anxiety returned with a vengeance. Without it none of my other medications work ( Prozac, Klonopin, Serouel) So I went back on it and I feel so much better. If you have the gene mutation Deplin is a must ! I wish you all the best.

Reply to  Joshua

You can also get a “clean compound” of this and many other medications at a specialty pharmacy, who will custom compound only the essential ingredients into a capsule form


I had been on prozac for 25 years and hated being on it. I took 2.5 years to slowly wean myself off of it and of course, I was then depressed. A new doctor recommended the genetic test and I came back with the gene mutation on both sides of my family. I started on Deplin and in about 7 days everything changed. Life is better than I can remember it being. I feel like myself and not numb with prozac. This is life changing and I’m so happy!

Reply to  Jean

Hi Jean, glad it works for you. I’ve been on it about 4 months now. It made a big change for me too after trying most of my life with everything. It is expensive. I’ve thought about alternative folate like some are suggesting here……….i’m just afraid to stop it and risk it.

Holly Way
Reply to  Patrick

I’m a pharmacist and have been researching. Looks like the largest amount of l-methylfolate allowed in otc’s is 1 mg. It would take 15 of that to equal one deplin 15mg. Don’t do it!


Deplin has been a lifesaver for me. Before taking it, NONE of my other medications were working. Anti-depressant, replacement hormones, Synthroid… and the list goes on. I had pretty much given up on life, and had no interest in anything. Within 2 weeks of beginning to take it, I was totally turned around. All my medications started working properly again, my energy level and mental outlook were back. I give it a 5 star rating!!

Reply to  Janis

Glad it’s working for you. I’ve tried EVERYTHING in the past 45 years! and nothing worked for me either. I’ve been on Deplin now about 2.5 months and it’s does help me alot. Very significant difference. It’s not curing everything i wish it would, but definitely “enhancing” alot. I’m more “me” and not as afraid to speak my mind to others where before I would panic and get angry because I took everything so personal.


Did this medication make anyone more depressed
I was told to take this and Metanix
I have been suffering with horrible panic attacks for the past two days and depression

Melissa Brown

Yesterday I was handed several samples of Deplin by my psychiatrist . He gave me no background information, no dosage recommendations so I am starting out clueless. Took like most patients with entrenched case of mood disorder many different medications for many years trial and error..with two exceptions all bad experiences. Not sure about this one either. Poured out a portion of first dose and. Seemed oky. How to proceed from here…thanks for this reply. Column…


I took deplin for 4 days
-I noticed a rash on day 3 but kept taking it
– on day 4 I went into anaphylaxis and went to ER.
– it was terrifying – my throat was swelling and I could hardly swallow

Reply to  Holly

Probably from all the dyes and other additives in Deplin.

Cheryl l

About to start this and my MD wrote for 15mg to start. I am 60 and have the genetic issue but no depression and now feel hesitant to start; especially at a top dose! I also do not like the ingredients in this stuff.. ones I avoid in ALL food, none organic, petroleum based dyes( ? For what?!?), glucose syrup solids…. From what source .. Cane or genetically engineered beets, soy lecithin, soy protein…. Both have high toxicity herbicide residues as the most genetically engineered food in the US, caseinate from cows…. What were they fed ? Are any if these imported? From where?
I was told I had to take this the rest of my life and I avoid ALL these horrible ingredients and do not eat processed foods. Am I trading a deficiency for daily doses of junk cancer causing ingredients?!? Really, can someone out there help?

Reply to  Cheryl l

Go to your health food store and buy their methyfolate. It is the same active ingredients as the prescription but none of the additives. They are generally one mg. so you would have to take 15 pills to equal one 15 mg. prescription. They work! It’s all natural. People with genetic defect mthrf gene need this form of folate to digest for their brain. Google it.
As I said it works!

Reply to  Jolynn

I agree fully! We go to a functional dr as well as the psychiatrist for my son. We both have the mutated MTHRF. He is also bi polar II. I was shocked at the garbage in deplin! He’s not suppose to have milk and I can’t have soy, not to mention the problems with the dyes! Duh! You would think medical “professionals would know not to give their patients this junk! Anyway, our functional dr gave us a Xymogene product (all natural and pharm. quality) Methyl Protect. My depression lifted after a week taking it 2X day! Great product!

Reply to  Jolynn

I was on Deplin and it helped but not my depression nor anxiety. To expensive for me and to many bad ingredients. I’m now on the natural methyfolate. Just started it and hoping it works. Btw, it’s half the cost of Deplin $26 for months supply vs $60 (with insurance) for Deplin. God bless!


I have been taking Deplin for over 1.5 years. At first the Psychiatrist, also a genetic doctor did a blood test to check for a mutation. I had the mutation, be it small, it was there. I have suffered with depression and anxiety for many years. Deplin was my life saver, and have not had an anxiety attack since I started taking Deplin. The cost may be a bit pricey but you can get your prescriptions thru Brand Direct and there price is cheaper. I too had pernicious anemia so I had to take vitamin b12, iron, vitamin C. I still have times that are bad but it helps much more than not. I always recommend that a person consult their physician but what I found out is that not all physicians know when to use Deplin correctly. This is not a medication for depression but for persons with the mutation that can cause depression, this is what Deplin should be used for. In the beginning it was great it was like turning on a light bulb, now that I have balanced out it does not seem to be having an affect but I know from being in the medical field that if I were to stop taking it my condition would revert to the state I was in before I started, so for me being not depressed, all the time is all I can ask.

Jan Sannik
Reply to  Delia

I’ve been on anti-depressants for many years and have never heard of being tested for a mutation, what is the mutation and what blood test was given?

Lisa Simkins
Reply to  Jan Sannik

So there is genetic testing you can do that will tell your psychiatrist if you have the gene mutation where Deplin would work for you. If your psychiatrist doesn’t do it find one that will. I am just hearing about the blood test. I wasn’t aware of that. When they do the genetic testing it confirmed I have Bipolar, PTSD, and ADHD. It is amazing. Not all insurance companies covers it.It took ten days for me to get the results. I am now on medications that will actually work for me, for years it was a guessing game, now this testing will help your doctor prescribe medication that will actually work with your DNA!

Reply to  Delia

I had the genetic test last month. After 41 years of Panic Attacks . 17 different meds and also finding only Xanax helped those. I became a nurse 30 years ago. I realized I have hidden depression when due to life changing accident 4 years ago. My Doc recommended the genetic test. I am almost absent of Serotonin and post gastric bypass surgery 8 years hence even less absorbed. Every Deplin dye I read has a form of iodine which I’m highly allergic to. I would really appreciate any answer to this Dilemma. It’s OK to email me. Thank you.


My doctor just prescribed Deplin to supplement my Wellbutrin and within a few days my low energy levels have improved GREATLY. I am exercising, cooking and sleeping much much better! My libido has also improved as this is usually nonexistent. I too had vivid dreams but I am also sleeping a lot deeper. The only issue is that my local Walmart price is $162 for 30 caplets! I found an online coupon which brought it down to $126! Does anyone know of a coupon I can use with greater savings?

Patty Kussner
Reply to  Lillia

Responding to Lidia:

I saw my doctor today and he’s considering Deplin for me to take in addition to the Wellbutrin, Lexipro, and Trazodone I currently take. Once my blood panel arrives he will talk with my psychiatrist to confer on drug therapy. Good news…..Deplin is now generic therefore the cost will be dramatically reduced.

Reply to  Lillia

I know it’s been a year so you may already have the info on Deplin. It is distributed by the pharmacy about 2 miles from my house. Get a 3 month prescription called in by doctors office. They are located in Covington, La. North of New Orleans. So unless you live nearby, they ship for $5. The company is Brand Direct and get doctor to call in rx for 3 month supply at $180/3months which is much less at $60/month. You can personally call the company as they have RN’s on staff to answer any questions. Good luck.

Reply to  Michelle

Thank you for the info on Brand Direct. I too am suffering from depression and have lost all motivation and desire to the things I use to love doing. The smallest of things seem like mountains. I’ve taken a leave of absence from work to get this corrected, I can’t tolerate feeling this way. My Dr is conservative and I’ve been on so many different prescriptions with limited results. Just received my samples of Deplin 15 on Thursday to add to my cymbolta. I like to check out the drugs and these reviews are very interesting and helpful. I had no idea the cost and on mine it says it’s manufactured and distributed by Nestle Health and Science. It’s only been 2 days but I’m hopeful I can receive the same benefits a lot of you all have. This is one disease that is so deviating if not properly treated and it’s always a guessing game. I wish the general public understood and realized how long it can take to recover and manage.

Debby Poindexter
Reply to  Lori

Lori, I feel your pain. I have the gene that causes depression and I have definitely recently been where you are. I am going to try the Deplin, but I am leary about some of the ingredients in it. Hope you are doing much better. It is such a debilitating disease.

Reply to  Lillia

Ask you Dr to send the prescription to Brand Direct. I pay half that amount!

Reply to  Anne

The amount I gave above which is $180 for 3 month supply is from Brand Direct who is the company in Louisiana who makes and sells Deplin and just got refilled this week Jan 2016 and price is exactly the same at $180 for 3 month supply. We walk into brand direct and personally pick it up and I have personally talked to the pharmacists who work at the facility. Deplin is the brand name made by Brand Direct. I cannot attest to it working as I do not take it but the ppl I have dealt with who do take it all say it is working for them.

Reply to  Lillia

GoodRX.com every day. This site offers discounts for drugs. The discounts change often so check it several times a day. The coupon must be used on the day that it is offered. Just print out the coupon and take it to your pharmacy. (CVS, Walgreens, Rite Aid). Good Luck.


My dad started to take Deplin. His mood has greatly improved but it’s also made him quite manic. It’s made him impulsive and unpredictable. I would use it with caution.



Yes Deplin is a prescription, however there are numerous other companies that make the same/similar product that does not need a prescription: Google Methyl Life and Metabolic Maintenance. Pamlab patented Deplin so that they could make some money, Methyfolate is Folic Acid that has been converted into the form that can cross the blood brain barrier. Folic Acid is water soluble so is safe at high doses. Look for products that contain Quatrefolic or Extrafolate S. Start with a low dose first and then work your way up. Good luck


You can easily tell if you need this medical food. There is a genetic test that costs around $200 (I think) that will tell you if you have the genetic mutation that prevents your body from converting folate to l-methylfolate. If you do have this mutation to a fairly severe degree than supplementing with deplin will help greatly. I have the genetic mutation at the second worst degree. That is some people cannot convert folate to l-methylfolate at all. I can convert it but at a reduced amount thus taking deplin has helped me a lot with depression and anxiety. My results for the genetic test are: compound heterozygous for the mutations, C677T and A1298C in the MTHFR gene. I felt better after taking deplin before I had the test done. My doctor thought the test was too expensive to try and since I was feeling better he thought there was no need to take the test but he was wrong. Knowing I have the genetic mutation means I will have to take this supplement my whole life and it validates my belief that it is not a placebo effect.

Reply to  Joe

Xymogene brand, Methyl Protect works wonderfully for those of us with MTHFR gene mutation. Find a dr that carries Xymogene! It’s a life saver without the added junk in Deplin!


I have been taking deplin for about two weeks and I have noticed a huge difference in my mood and less anxious than I have been in a while. I am trying to decrease my medication that I am now on which is cymbalta bucebar and trazadone. I didnt want another pill to help me through my panic attacks and depression so I looked for a more natural outlook and I hope it helps you out as it did to me.


I was diagnosed with pernicious anemia 15 years ago. I was no longer able to feel differences in temperature (hot or cold), texture ( sand paper from silk), and when I walked, I could not feel my feet touching the floor. My proprioception was completely messed up, and at night, if needing to get up for any reason, I could not tell if my hands were touching the wall or not, and would walk directly into a wall unless the light was on. I have been taking vitamin B12 by injection bi-weekly all this time, and there had been no difference. When my psychiatrist prescribed Deplin, a vitamin form that crosses the blood brain barrier, within 2 weeks, I could feel temperature, textures, and am not as clumsy as before. It is a miracle drug.


I used 4 kinds of anti-depressant in the past namely: citalopram, paxil, welbutrin and cymbalta. After 7 moths of citalopram, I developed an allergic reaction: itching and rashes on my arms and face. With welbutrin SR i experienced palpitation, insomia and depression. I’m experiencing bad side effects of menopausal like hotflashes and anxiety. I was desperate because I had to be out of work for six weeks. I’m under stress too that i feltpressure on my left chest. My stress test and EKG results came back normal. On my last visit to my doctor, she prescribed deplin that could be taken alone or in combination with an antidepressant. After 2 weeks, i feel better and the pressure is gone. Although it is expensive I have no other choice but to take it but it’s worth the money.


I just started a few days ago and it is working!
I did have had very realistic dreams, but nothing frightening. In fact I had a good dream and went back to sleep to go back into it. I dream a lot anyway, so perhaps it’s not the deplin.
I also do amino acid therapy and use a light box or bright light visor which helps enormously. I have been in a deep depression and now that I am better- it feels like a miracle.
BTW, I take lithium and lamotragine for BP
I have no problem that this isn’t natural-that doesn’t really mean anything in terms of results-and certainly, if it’s going to help me save my life, abd the only side effect is intense dreams, I’ll keep taking it-especially during a dreary winter.


For anyone fighting with what turns out to be Refractory Depression I highly advise looking into Low Dose Naltrexone. I am alive living a happy productive active life today because of this cheap, off patent drug with little to no side effects and the other benefits it carries for overall health is amazing. Visit our Facebook page, ask for admittance and start reading the document selection.


It worked FANTASTIC for the first 3 days, then slowly diminished. Now for the first time in my life, I cry over well, – things. NEVER have I done that prior to taking this. I’ve stopped taking this, and am going to see if this is indeed the culprit.


I have found Deplin 7.5 to be extremely beneficial in my treatment of bipolar disorder. I was trying many different anti-depressants and having a terrible time and then was introduced to Deplin. I take it in combination with Celexa, Wellbutrin, and Lithium and have been stable for almost 8 months. The trick is to find a great psychiatrist.


blood pressure stayed normal. moods nicely stabilized. seems to work well for me. tired of feeling like a trainwreck all the time.


I should have known deplin wasn’t going to do what I needed…..by the second time I met with dr Steven Lamm, I knew he was a quack. The doc was all jittery and seemed to be on powerful stimulants. He had given a bag full of different supplements he told me were samples. When the nasty receptionist told me I owed hundreds of dollars for the supplements, I should have just walked out. Instead, I paid and went to the drugstore with my prescription for the deplin…..

I have been taking deplin for 3-4 months. I have nutty dreams, wake up many times every night to urinate or just with so many thoughts jumping around in my head and have a difficult time going back to sleep. This had never happened to me before.

Now, all I wanna do is to find out how to wean off deplin and live a natural life.

Angela W

This is a wonderful supplement to any depression therapy. It is obvious that many folks on here are NOT scientific or medical, and I am both. I personally use it, and it helps with energy, as well as depression levels.


I am taking Celexa and still struggling a bit with depression. (genetic) My doctor suggested Deplin. I have been taking it for almost 4 weeks and IT HAS DEFINITELY MADE A DIFFERENCE. No side effects. I didn’t realize it was making a difference until I reflected upon the last couple weeks. So grateful. Now I need to find out how much it will cost. Single and limited income.


Deplin isn’t an antidepressant. It is the natural, active form of folic acid(Vitamin B9). It’s called 5-methyltetrahydrofolic acid or Metafolin and Deplin is just a high dose of it. For this reason, you don’t need a prescription. Many people have certain genetic polymorphisms that reduce the conversion from folic acid to its active form, which is quite bad because it is necessary for the production of neurotransmitters like serotonin. That’s the reason it works so well with antidepressants. The body produces more neurotransmitters like dopamine and serotonin and the antidepressants inhibit their reuptake. That is one reason antidepressants don’t work well for many people.

Adam wrote that he had big trouble with it. Maybe he has an additional Vitamin B12 deficiency(anemia), which was unmasked by Metafolin/Deplin. Maybe slow titration and a B Complex and Vitamin B12 may help. You have to treat the Vit B12 deficiency otherwise permanent neurological damage may occur!

Reply to  PhoenX

Folate is the natural form. Deplin is a man-made version, L-methyl folate, and is available by prescription only. It is not an antidepressant but seems to help with depression, depression related to bipolar disorder, and schizophrenia. This is the active form of folate by prescription, but I wouldn’t take mega-doses of anything over the counter–folate or not– without medical advice.

Reply to  PhoenX

Amen your right on I buy my product through seeking health the active form of folate for the Mthfr mutation deplin is garbage it has a dye in it . People with this mutation need to detox not take dyes

Cheryl McAllister

This is the first antidepressant that has worked for me. I have BP and have been through some long spells of depression; the most recent was a weepy deep depression. After about a week of Deplin 15mg, I was no longer weepy and feeling depressed, but was still somewhat flat. Now at the end of 2 weeks, I feel somewhat close to normal (which I have not felt in a long time). Yes my dreams are more vivid and realistic but my days of feeling better have outweighed any dream that has lingered past my morning coffee. I think Deplin in combination with Lithium and Trazodone is the right mix for me and my BP. Feeling in control of my emotions for the first time in a LONG time and it feels great!


This is alot more serious than most realize I believe. I had a horrible reaction and I will never touch this stuff again and would Never recommend, actually I vote Nay for anyone. U will get just as good of results w a proper diet and some amino’s. And No sides! THIS IS SERIOUSLY DANGEROUS! and not worth the small benefit to see whether or not u will end up in er bc of spiked blood pressure. ! Rediculous.

Reply to  Adam

I wouldn’t say nay to everyone. It worked amazingly well for me. I had energy and felt alive for the first time in my life after a life of depression and constant fatigue to the point where it was exhausting to even get up, shower ect. I have tried everything from many different medications, eating healthy, taking vitamins and excercised as much as I could even if it was a just a short walk, almost daily (which I still do). Taking this with Wellbutrin has literally given me the life I always wanted. I feel “normal,” as in feel like I have the energy to do daily things and the motivation to do more than ever before. It’s not miracle fix and the affects may not always be this great but it’s been 6 months and I am so grateful to have found and tried methyfolate. So for people reading this I think it’s important to give your honest opinion and experience. People should know the good and the bad. Of course this will not help or be a good thing for everyone but it could help people.

Reply to  Adam

Adam, as a healthcare worker, I have seen sudden anaphylaxis from something as innocent as a box of apple juice. Having a severe reaction to anything is very scary. Also as an example, you can live on a farm and been stung by bees many times in your life without a reaction and then you get stung and your throat swells shut. We can have a reaction to thing we used to be able to take or eat. Nuts and seafood are 2 big ones. But the point I wanted to make for others reading thee comments in that different ppl react to different drugs. I may be severely allergic to penicillin while you can take it without any problem. So because you did have a reaction, it doesn’t automatically make this a dangerous product for all people.

Judy Williams

I’ve been taking deplin one month now for major depression along with my anti depressants and I’ve noticed a tremendous difference. I’m 63 and I too am on ssd and pay for anthem insurance but deplins not covered. Why is it so expensive?


I started using Deplin 1.5 years ago. I noticed an improvement in my mood by day 3. I’m not flying high and happy but it definitely keeps me out of those low lows. I was tested and I do have the mutated gene which doesn’t allow for Folic Acid to be properly processed. I will need this the rest of my life. I do hope the price comes down.

Susan Easterday

I have been on Deplin for about a month. I have not had any side effects, but note tingling in feet and hands. I am on Lyrica for neuropathic so. Just curious if the tingling issue from the Deplin or perhaps it is due to the Fibro or RA that I have been Dx with. Curious, will this assist with weight loss.


I wish they offered a free trial, but I managed to find a 50% discount coupon, which dropped the price to an almost decent level. After trying it for two weeks, I can say that the price is well deserved, because it definitely lives up to its promises.

bill aslin

I suffer from depression and have been for many years. I would like to try deplin. I am 67 years old and draw social security and I have medicare. I would like a free sample.

Leslie Billings

Deplin Algal oil works very well for me. But as a 70-year-old retired person on a fixed income I have a very difficult time paying for it. My psychiatrist thinks it is helpful for my depression he prescribed it. How long will it be before the FDA approves it and my insurance pays for it? Thank you for this page the information is most helpful.

Milagros Feliciano-Cruz

I just wanted to know specific side effects since I do take other medications such as Clonazepam, Lamictal, Depllin, Restoril and Brintellix. Thank you

Iulian (Editor)

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.