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Mydayis Review – Is it Effective?

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Summary | Nutrition Info | Claims | Adverse Effects | Cautions | Cost | Where to Buy? | How To Take | Bottom Line

Mydayis (brand name) is a stimulant prescription medication used to treat attention deficit hyperactivity disorder (ADHD) in adults and children ages 13 years and older.[1]

ADHD is a multifaceted neurodevelopmental disorder that can affect a child’s relationships and success at school. There are no apparent symptoms of ADHD, making this disorder hard to recognize in many cases.

Any child may undergo many of the individual symptoms of attention deficit hyperactivity disorder. ADHD is usually diagnosed in children by the time they’re adolescents, with the average age for moderate ADHD diagnosis being seven years.


1) What is Mydayis?

Mydayis is a stimulant prescription medication that contains a mixture of four amphetamine salts: dextroamphetamine saccharate, dextroamphetamine sulfate, amphetamine aspartate monohydrate, and amphetamine sulfate.

Mydayis belongs to a class of medications called stimulants. The formulation is similar to Adderall’s formula and contains four amphetamine salts called “mixed amphetamine salts.” Mydayis is available in an extended-release capsule taken orally.[2]

Extended-release drugs gradually enter your bloodstream so that you have a constant level of the drug in your body all day.

Please note that Mydayis is a black box classified drug. This is the most severe warning from the Food and Drug Administration (FDA), and it warns physicians and patients about the drug being potentially dangerous or highly addictive.[3]

The four amphetamine salts found in Mydayis’ formula are powerful stimulants that can potentially be abused if not taken as prescribed. This may lead to high blood pressure, a fast heart rate, aggressive behavior, anxiety, and in rare cases, early death.

2) The Company Behind Mydayis

The FDA approved Mydayis (mixed salts of a single-entity amphetamine product) for the treatment of ADHD in 2017.[4] For the United States, this prescription drug is made by Shire Pharmaceuticals.

Shire Pharmaceuticals is a Jersey-registered specialty biopharmaceutical company. Originating in the United Kingdom with headquarters in the United States, its brands and products include popular prescription drugs such as Adderall XR, Lialda, and Vyvanse. Takeda Pharmaceutical Company acquired Shire Pharmaceuticals and all its patents on January 8, 2019.

Shire Pharmaceuticals LLC contact information:[5]

  • Phone: +1 617 349 0200 (United States) / +41 0 41 288 40 00 (Internationally)
  • Address: 300 Shire Way, Lexington, MA 02421, United States;
  • Website: shire.com
Nutrition Info

3) Ingredients of Mydayis

Mydayis contains the following active ingredients:

  • Dextroamphetamine saccharate
  • Dextroamphetamine sulfate
  • Amphetamine sulfate
  • Amphetamine aspartate monohydrate.

4) What Does Mydayis Do?

Two Cochrane reviews[6][7] on the treatment of ADD/ADHD in subjects of all ages with pharmaceutical amphetamines asserted that short-term studies have demonstrated that these drugs decrease the severity of symptoms. Still, they have higher discontinuation rates than non-stimulant medications due to their adverse side effects.

Another Cochrane review on the prescription of ADD/ADHD in children with tic disorders such as Tourette Syndrome showed that stimulants, in general, do not make tics worse.[8] Nevertheless, large doses of dextroamphetamine could worsen spasms in some patients.

Several clinical reviews and studies confirmed the effectiveness and safety of long-term, uninterrupted amphetamine salts used to treat ADD/ADHD. Long-term continuous stimulant therapy for ADHD is effective for enhancing the quality of life and academic achievement, reducing the core symptoms of ADHD (i.e., impulsivity, inattention, and hyperactivity).

This form of therapy is also effective at producing improvements in a large number of functional outcomes across nine categories of results related to antisocial behavior, academics, non-medicinal drug use, driving, obesity, self-esteem, occupation, social function, and service use (i.e., occupational, academic, financial, health, and legal services).[9][10]

Dextroamphetamine and amphetamine are central nervous system stimulants. They impact chemicals in nerves and in the brain that contribute to hyperactivity and impulse control.

In five clinical studies,[11][12][13][14][15][16] Mydayis was found to ease ADHD symptoms when compared to a placebo (no treatment).

In each of the five studies, patients with ADHD were given either Mydayis or a placebo. Each study included adults as well as teenagers ages 13 years and older.

All participants were assessed with ADHD rating scales at the start of each study and throughout to measure how their symptoms progress or ease.

At the end of each study, ADHD symptoms had lessened significantly in the patients who took Mydayis correlated to those participants who were given a placebo.


5) Mydayis Claims

Mydayis claimed benefits include:

  • Once-daily treatment that lasts up to 16 hours after dosing;
  • Provides improved attention in ADHD up to 16 hours after dosing;
  • The first ADHD treatment to offer triple-bead delivery for the extended-release of medication;
  • Safer than other similar prescription drugs.
Adverse Effects

6) Potential Mydayis Adverse Effects

Common side effects of Mydayis[17][18][19] may include:

  • Insomnia
  • Dry mouth
  • Feeling jittery or anxious
  • Reduced appetite
  • Feeling restless
  • Irregular or painful periods
  • Erectile dysfunction
  • Weight loss
  • Diarrhea

Serious side effects from Mydayis aren’t common, but they can occur. Serious side effects of Mydayis may include the following:

  • Risk of stunted growth in children and teenagers
  • High blood pressure
  • Depression
  • Heart palpitations (feeling of skipped or extra heartbeats)
  • Loss of awareness or consciousness
  • Rapid heartbeat
  • Stroke
  • Heart attack
  • Aggressive behavior
  • Jerking movements of the arms and legs
  • Impaired and delusional thinking
  • Cold or blue-colored fingers and toes
  • Agitated or irritable behavior
  • Temporary confusion
  • Random pain or tingling in the fingers and toes

7) What You Need to Know Before Taking Mydayis

While Mydayis is advertised as a less dangerous prescription drug, it may still interact with several other prescription drugs. Do not take Mydayis if you are already taking one of the following medicines:

  • Levothyroxine
  • Abilify (aripiprazole)
  • Propranolol
  • Klonopin (clonazepam)
  • Prozac (fluoxetine)
  • Spironolactone
  • Trintellix (vortioxetine)
  • Vyvanse (lisdexamfetamine)
  • Buspirone
  • Zyrtec (cetirizine)
  • Bupropion
  • Singulair (montelukast)
  • Clonazepam
  • Xanax (alprazolam)
  • Cymbalta (duloxetine)
  • Gabapentin
  • Trazodone
  • Lamictal (lamotrigine)
  • Lamotrigine

If you’re planning about becoming pregnant, discuss the use of Mydayis with your physician. Animal studies indicate a potential risk of fetal harm.[20][21][22] Infants may be born with low birth weight, prematurely, have motor or learning deficits, or experience withdrawal. Mydayis is passed through breastmilk, so it is recommended that mothers do not nurse while taking it.

Where to Buy?

8) Where to Buy Mydayis

As a prescription drug, Mydayis can be purchased from most pharmacies across the United States.

Shire Pharmaceuticals offers a small discount in the form of a discount card on your phone. Simply take it to the pharmacy with your prescription and save between $30 and $60 on each refill.


9) How Much Does Mydayis Cost?

The price for Mydayis oral tablet, extended-release 12.5 mg, can reach $1,028 for a supply of 100 tablets (up to $10,28 per tablet). A generic version of Mydayis is available in the form of an amphetamine and dextroamphetamine mixture.

If you prefer a less stimulating and lower-priced alternative to Mydayis, we recommend checking out ADDTabz.

10) What Are Mydayis Alternatives?

Because Mydayis is a prescription drug, we can only review other prescription medicines as potential alternatives. We don’t advocate substituting a treatment directed by your physician with an over-the-counter dietary supplement.

Concerta (Methylphenidate) is a controlled substance used to treat attention deficit hyperactivity disorder (ADHD). It works by activating the areas of your brain that are responsible for paying attention and staying focused.[23]

Concerta is available as an extended-release tablet in various strengths: 18 mg, 27 mg, 36 mg, and 54 mg.

Vyvanse is a brand name for a drug that contains lisdexamfetamine.[124] When lisdexamfetamine enters the body, it is changed to dextroamphetamine. Vyvanse is available in one formula and is effective for approximately 14 hours.

The FDA approved this prescription drug in 2007 and is prescribed to treat people six years and older.[25] In addition to treating ADD/ADHD, lisdexamfetamine can also be prescribed to treat binge eating disorder.[26][27]

Adderall is considered a first-choice treatment option for ADHD. Studies show that it improves attention, focus, and reduces impulsive behaviors.[28] Between 75% and 80% of children with ADD/ADHD will see improved symptoms with the use of stimulant prescription drugs.[29] Adderall is also a valid option for increasing daytime wakefulness in individuals with narcolepsy, although there is little related research.

How To Take

11) How to Take Mydayis

For teens, the recommended starting dose for Mydayis is 12.5 mg once daily in the morning. For adult patients, this prescription drug is available in four strengths: 12.5 mg, 25 mg, 37.5 mg, 50 mg.

12) Of the Same Product Line

Mydayis comes as an extended-release capsule, and it’s available in four strengths: two strengths for teens (12.5 mg and 25 mg) and two strengths for adults (37.5 mg and 50 mg).

13) Mydayis Reviews

"I've been taking meds for ADHD/ADD close to 8 years now. Tried Adderall at many dosages, types, and amounts of times per day over many years. My biggest issue. I forgot to take them. I tried Vyvanse." [Read full review]


"I asked my doctor about Mydayis because it lasts 16 hours. The first week I was so calm, never been so calm in my life, even with antidepressants. I was able to focus on conversations." [Read full review]


"I am diagnosed with Concurrent Concussion Syndrome with ADD symptoms. I took Vyvanse for over a year, and I thought I loved it until I realized it gave me anxiety because I was trying to cram 16 hours' worth of homework and chores into the short period the medication worked. " [Read full review]

---Madison Grooters

Bottom Line

14) The Bottom Line – “Does it Work?”

Mydayis includes the same active ingredients as Shire’s well-known ADD/ADHD prescription medication Adderall but is formulated to help alleviate symptoms for up to 16 hours post-dose.

While ADD/ADHD is more commonly thought of in childhood or adolescence, Mydayis is targeted more towards adult patients. In essence, a group Shire Pharmaceuticals pegs as the fastest-growing segment of the ADHD market.

3/5 - (6 votes)

Reference Sources

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