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Cogni-Q Review – 8 Things You Need to Know

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Synopsis | Nutrition Facts | Benefits | Contraindications | Price | Suggested Use | Does it Work

Cogni-Q is a nutraceutical designed to support cognitive function with particular benefits on memory. The supplement is produced by Quality of Life, a company with a history of over 15 years in the field. The manufacturer prides itself with several awarded formulations such as AHCC-a patented medicinal mushroom extract, Oligonol- an innovative formula with anti-aging benefits, or VitaPQQ- the first dietary formula to feature the vitamin PQQ designed to preserve mitochondrial function. Quality of Life also claims to be dedicated to providing formulas that contain meaningful dosages of key ingredients, an essential condition of high-potency products.

Cogni-Q is based on a single active ingredient which is a patented extract of the Korean plant Angelica. The plant-derived compound is known as INM-176 and is a clinically researched substance. The manufacturer claims this chemical has been shown in a published double-blind, placebo-controlled trial to support cognitive agility in 80 subjects suffering from mild memory problems associated with aging.


1) Cogni-Q at a Glance

INM-176 is a standardized ethanolic extract of the plant Angelica gigas Nakai used as a traditional Korean remedy as a general tonic, to improve gynecological health, and support the immune and cardiovascular systems. Currently, the plant is being investigated as an anti-cancerous treatment, but its effectiveness has not yet been confirmed by clinical trials.

INM-176 has been primarily investigated as a neuroprotective agent in patients suffering from Alzheimer’s and other age-related cognitive problems. An animal study concluded that due to its anti-inflammatory action, the compound can be a potent neuroprotective and cognition ameliorating agent. Human trials have also shown positive outcomes. One of these studies is mentioned by the manufacturer on the official page of Cogni-Q. The subjects who were administered with the INM-176 compound had a significant decrease in total error score in the Alzheimer’s Disease Assessment Scale-Cognitive section as opposed to those who were administered with placebo. The INM-176 group was also favored by the mean changes in instrumental activities of daily living (IADL) and geriatric depression scale (GDS) as compared to the placebo group. Another study involving 92 participants (elder individuals suffering from a cognitive impairment) showed similar results.

Nutrition Facts

2) Cogni-Q Nutrition Facts

Cogni-Q contains the following ingredients: Cogni-Q contains the following ingredients: Angelica gigas Nakai (root) extract (INM-176), Decursin, Decursinol, rice flour, vegetable cellulose, and Leucine.

3) What Does Cogni-Q Do?

INM-176 is an herbal extract composed of Decursin and Decursinol. The chemical has been clinically researched for potential benefits in patients suffering from ADD, ADHD, or age-related memory problems. Human studies seem to support the benefits of INM-176 in the cognitive area. One study involving 30 patients diagnosed with ADHD showed significant changes in attention, impulsivity, hyperactivity, and executive and cognitive functions. Another human study involving elderly subjects who suffered from cognitive impairment has managed to reveal improvements of memory and other cognitive functions.

Researchers discovered that INM-176 has the ability to inhibit an enzyme that breaks down Acetylcholine. The name of this enzyme is acetylcholinesterase. By breaking down this neurotransmitter, its concentration in the brain decreases, leading to various cognitive issues, memory decline being only one of the numerous problems associated with Acetylcholine deficit. More so, INM-176 is able to protect the brain against the damage of free radicals, particularly from the oxidizing peptide beta-amyloid (Abeta).


4) Cogni-Q Benefits & Results

  • The formula is based on a patented and clinically researched compound which has shown positive outcomes in both animal and human trials.
  • The formula is available at various online stores, some offering discounts.
  • The monthly cost of Cogni-Q is moderately low.


5) Cogni-Q Warnings and Precautions

  • The manufacturer offers a restrictive return policy (only available for 30 days). Only unopened bottles are accepted.
  • The number of consumer testimonials involving this formula is limited. A large percentage of the few consumers who reviewed the formula complain about the ineffectiveness of the supplement.


6) Cogni-Q Price

Cogni-Q is available at multiple online stores, including on the official site of the manufacturer. The standard price is $34.95, and this is the cost for a month supply. At this time the formula is on sale at some partners, so you can buy it cheaper from the Quality of Life website. No other offers seem to be available at this time. The manufacturer’s refund policy is restrictive in the sense that only unopened products are accepted and no later than 30 days after purchase. The policy applies solely to the products ordered directly from the manufacturer’s website.

Suggested Use

7) Suggested Use

Scientists observed that INM-176 works by increasing Acetylcholine levels in the brain. AC is an important neurotransmitter involved in brain cell signaling. It is why without adequate amounts of AC in the brain, neuronal communication becomes impaired leading to memory problems and communication issues. Age-related memory decline has also been associated with AC decline, so INM-176’s ability to help maintain Acetylcholine levels in the brain is essential for preventing memory problems.

Does it Work

8) Bottom Line – Does It Really Work?

Cogni-Q looks like a high-quality formula because it is manufactured by an experience and awarded manufacturer, and it contains a single patented and clinically researched key-ingredient. However, the product does not benefit of the consumers support at this time. A reduced number of consumer testimonials are available for online consulting. The reviews are mixed. However, the existing clinical evidence seems to support INM-176’s antioxidant and neuroprotective benefits. More research is required in order to reach a definitive conclusion, as the number and scale of clinical trials conducted so far are reduced.

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