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Calm PRT Review – 9 Reasons Why

By Robert Rivera

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Synopsis | Formula | Pros & Cons | Potential Side Effects | Cost | Where to Buy? | Directions | Final Thoughts

Calm-PRT is a brain supplement advertised to assist with stress reduction, promote sleep and reduce excitability.

The manufacturing company NeuroScience claims the formula works by restoring communication within the hypothalamic-pituitary-adrenal (HPA) axis, hence reducing Cortisol and catecholamines released as a response to stress.

Because Calm-PRT helps restore a healthy HPA axis, the product is especially suited for patients with elevated levels of epinephrine, Norepinephrine, and Cortisol, but can also be useful for anyone trying to cope with stress.

The question is, can Calm-PRT actually help us calm down and get good sleep? Read our Calm-PRT review to find out.


1) Calm PRT at a Glance

  • Standardized ingredients
  • Helps with memory
  • You need to register an account before you know how much it costs

2) The Company Behind Calm PRT

NeuroScience is a company founded in 1999 and headquartered in the United States. The company specializes in laboratory tests and clinical tools that target the neurological, endocrine, and immune systems.

Additionally, a dedicated line of products targeting the spectrum of neurotransmitter imbalances has been developed and currently includes more than 50 different products.

The company’s official website is comprehensive and offers extensive information on various health conditions and company products.

You may contact NeuroScience through the following:

  • Contact form https://www.neuroscienceinc.com/contact/
  • Phone customer support at +1 (888) 342-7272
  • Email at customerservice@neurorelief.com
  • Fax at (715) 294-3921.

They are open from Monday to Thursday 8 AM to 5 PM, and 8 AM to 1 PM on Fridays.


3) What Are Calm PRT Ingredients?

Calm-PRT includes the following ingredients:

  • Rhodiola Rosea root extract (standardized to 16% rosavins)
  • Phosphatidylserine 50%
  • L-Glycine
  • Taurine

Other inactive ingredients: Vegetable cellulose (vegetarian capsules), rice flour, and magnesium stearate.

Calm-PRT is a combination of herbs, amino acids, and other nutrients designed to fight stress.

The formula contains Phosphatidylserine, a substance naturally found in the brain in high concentrations. This is a fatty acid believed to play an important role in neuro-transmission.

  • Decreased levels of Phosphatidylserine caused by aging processes or other causes have been linked to memory impairment, depression, Parkinson’s, and Alzheimer’s disease.

Rhodiola Rosea is a remarkable adaptogen with a variety of uses throughout history.

Particularly known for its adaptogenic and tonic properties, the plant has been used to:

  • strengthen the nervous system
  • fight depression
  • improve energy levels and memory
  • increase sexual function
  • assist with weight loss
  • enhance immunity
Pros & Cons

4) Calm PRT: Pros and Cons

  • Calm-PRT contains no wheat, corn, salt, sucrose, starch, yeast, artificial flavors, artificial colorings
  • May contain soy due to phosphatidylserine
  • The main ingredients have been researched and documented evidence of their effectiveness exists
  • Generally positive consumer reviews available online
Potential Side Effects

5) Potential Side Effects from Calm PRT Ingredients

Calm PRT contains ingredients that when taken at below the suggested use may cause over-excitation, jitteriness, or agitation.

Where to Buy?

6) Where to Buy Calm PRT

You can buy Calm-PRT from their official website or through Amazon.


7) How Much Does Calm PRT Cost?

The official website requires you to register before you get to know the price, but Amazon pricing suggests a bottle that contains 90 capsules costs $152.95.


8) Directions For Taking Calm PRT

Take 3-4 capsules on an empty stomach one to two times daily or as directed by your healthcare provider. Do not exceed suggested use.

Final Thoughts

9) Final Thoughts on Calm PRT

Calm-PRT desires to reduce the over secretion of specific stress hormones and promote a normal, healthy response during stress-related conditions, which can translate to better sleep too.

The formula has received positive consumer reviews, although not many. It is likely that the formula will work as advertised, however, you should be cautious as some ingredients are known to cause side effects.

Now, the question is, does your budget allow for this type of anti-stress supplement? We think for that price, you can buy more than a handful of quality nootropics that can do the same thing.

For the price alone, we’re going to have to recommend other anti-stress supplements.

5/5 - (2 votes)
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TK cannon

I suffer from ADHD. I was proscribed adderall at a early age. I am now 45. I have dealt with my condition for many years. I have been taking this product for about a month now. I no longer take adderall. My family and friends have noticed a huge improvement in my ability to focus (not so spastic). As I will always struggle with my condition this product does help and I do recommend it if you struggle with anxiety and focusing on one thing at a time..

Title for your comment
It works for me.
Have you tried this product?
Kathy J

I’m very impressed with this product. I’ve tried many other products with minimal results, but this was just as potent as some of the pharma samples my doc gave me. I had no side effects, and after two days was very relaxed and care free. Wish it were cheaper, but I will buy again.

Title for your comment
Worked like a charm!
Have you tried this product?
cathryn Dimucci

Ive been taking this product with Kavinace for over a year now. and has done wonders for me, is there any bad side effects to this product


I am recovering from lyme disease and upon going off antibiotics I had severe, relentless insomnia. 1-2 hours night of sleep MAX. I tried melatonin, tryptophan, sleepy tea, ashwaganda, valerian, benadryl and probably unsafe large cocktails of all combined.

After a week of no sleep, my naturopathic doctor suggested this and after about 3 days my sleep normalized. I have reduced my dosage and should be off it completely in a month or so. Apparently the disease had really screwed up my HPA regulation and this seems to have corrected it. Expensive – but a miracle drug for me.

It did give me a drunk sort of feeling the first two or three days but I rarely get that feeling now and it is fleeting.


This remedy had the opposite effect on me. Since I have started utilizing it, I became more anxious and nervous and sometimes even aggressive. I don’t know what they are putting in these pills, but I immediately stopped the treatment and swear to never take it again.

Rebecca H.
Reply to  Jonette

It’s true that CalmPRT can have the opposite effect if a lower dose is taken. You really can’t take just 1 at a time it has to be 2 or 3.


I’ve been taking Calm-PRT for a couple of months, and do feel it has helped me. I feel less stressed and more centered. I’m going to sleep a bit earlier and more easily than I had been before, which is good. The two other neuroscience products I tried were terrible for me (Travacor, Adrecor) but this one has been worth it.


This is one of the best products I have ever used. I don’t agree with the article above. I am well versed in neurophysiology and the combo of calm prt and kavinace helped me within days when I had been depressed and near suicidal for many months. You are on these as well as a blend of amino acids for two months and you can climb out of any hole. Thank god for these two supps.

Claudia Ye
Reply to  carla

Thank you for your comment. I started taking it a couple of days ago, but ig gave anxiety, then the doctor combined it with Kavinace and it worked just outstanding!! I am happy I dont have to take so many sleeping pills since I discovered Kavinace!

Kimberly Flores

Calm-PRT was recommended to me by my doctor because I couldn’t sleep while going through a very stressful period. It helped me feel more calm and balanced. I could sleep better, without feeling groggy the morning after. I always a bottle in the house for emergency cases, but I’m not sure about taking Calm-PRT daily, without interruptions.


What is the best 2 times to take the 3 CalmPRT. I am not sure and have been told 2 different things from 2 people. I suffer high nighttime cortisol and tend to wake every 2 hrs all night long.

Diane Powell
Reply to  LUANN

Luann- My cortisol was high at night [about 2-3 oclock i would wake and be unable to go back to sleep sometimes]. My ND found insulin-resistance and recommended dietary changes. I’ve also used calm-prt for nearly 2 yrs. 3-4 capsules before supper [empty stomach] and it helps me destress and wind-down so i can sleep. hate spending so much but cant seem to do without it. what i eat all day seems to be important too- staying away from caffeine helpsj-tho it can be really hard. I also react badly to valerian -which is supposed to be relaxing- it does not help me sleep. hope this helps.