Home » Reviews » Mood Supplements » 5-HTP Mood Positive Review

5-HTP Mood Positive Review – Is it Effective?

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Facts | Nutrition Facts | Pros & Cons | Cautions | Cost | How To Take | Conclusion

5-HTP Mood Positive enhancer is a widely known natural supplement that is believed to be the remedy for poor appetite, bad moods, insomnia, anxiety, and depression. It is said to be a naturally occurring plant that is produced by Natrol. The head office of Natrol is in the US. The company is known for over 30 years in the supplement industry. It has a wider market in and outside of the United States. They have a good track record and its products go through a rigorous quality assurance and control tests. Other products that are produced and sold by Natrol are:

  • Nature’s way Gastritix
  • Nature wise 5-HTP
  • Natrols 5-HTP Time

According to the manufacturer, the product is claimed to have about 100 mg of 5-Hydroxytryptophan extracted from the simplicifolia seed, water, rice, magnesium, silica, and flour.

On the manufacturer’s website, usage of Natrol 5-HTP mood enhancer should not be used by women who are pregnant or breastfeeding. Any person above the age of 18 can, however, use it if they are not on prescription medicine. Consult with your doctor before using.


1) 5-HTP Mood Positive Quick Facts

5-HTP Mood Positive contains several ingredients. The active ingredient has a component that is extracted from the seeds of a herb known as Griffonia Simplicifolicia. The component is 5-hydroxytyroptophan. It is said to be the ingredient that aids in the creation of serotonin and melatonin.

Serotonin and melatonin are neurotransmitters that are natural mood regulators. They help in sleep patterns, emotional balance, and appetite restoration. Science has discovered that they also have a role in managing depressions and decision-making processes in the brain. Natrol 5-HTP is ideal for senior citizens as it said that serotonin production declines with old age. People in this age group are likely to suffer from depression, insomnia, and anxiety. In as much there may be a link that the product increases the levels of serotonin more research is needed in this area.

5-HTP Mood Enhancer may be linked to some diseases that cause muscle pain. This may be linked to Peak X another Amino acid and a component of Tryptophan believed to be found in 5-HTP products. One of the documented side effects of this supplement is nausea (this is backed up by clients’ reviews on the product website). On treating depression, the results have not been convincing. The recommended supplement industry dosage standard is 50 or 100mg. Each package has about 50mg of 5-HTP.

Nutrition Facts

2) 5-HTP Mood Positive Nutrition Facts

5-HTP Mood Positive contains the following ingredients: Vitamin B6 (10mg), Folate, Folic Acid, Folacin (200mcg), Vitamin B12 (50mcg).

Other supplements use 5-HTP as part of a serotonin formula. If interested, check out our BrainMD Serotonin Mood review.

3) Does 5-HTP Mood Positive Work?

Natrol 5-HTP is believed to contain an active ingredient that plays a key role in enhancing mood. L-Theanine is derivative of green tea that has been separated from caffeine. L-Theanine increases brain activity that is linked to calmness and relaxation. It is said to be a powerful combination of folic acid, vitamins B12, and B6 that helps maintain emotional stability and reduces drowsiness. Other benefits that are attributed to it are the general feeling of happiness and wellbeing, tames anxiety and it is 100% nonprotein.

It is recommended that one takes a single tablet two times in a day for a period of not less than two weeks but not exceeding two months for one to start noticing the benefits in full.

Pros & Cons

4) 5-HTP Mood Positive: Pros and Cons


  • Well reviewed by many consumers.
  • With a price range of $16 -$20, it is quite affordable.
  • The supplement is manufactured a world-renowned company.
  • It is a naturally occurring supplement.


5) What You Need to Know Before Taking 5-HTP Mood Positive

  • It may not work well if you are using clinically approved medicines.
  • Cannot be used by pregnant and lactating mothers.
  • Not to be used by anyone under the age of 18.
  • 5-HTP does not have scientific backing.

6) 5-HTP Mood Positive Cost

Natrol 5_HTP is generally affordable in the market with a price tag in the range of $16-$20. The product is readily available from the manufacturer’s website and other health supplement shops near you. There is free shipping option to your residence at about $35, while shipping to the store is offered for free. The shipping period is about 1-3 business days within the United States. There are no shipping restrictions on this product. Buyers who use cards earn 100 points on every dollar spent on vitamins.

How To Take

7) How to Take 5-HTP Mood Positive

On a general scale, the supplement is effective on mood-related symptoms.


8) Conclusion

The product is based on an amino acid derivative 5-HTP that is clouded in endless controversies. There are many side effects that are still unknown. It works to stimulate serotonin production while at the same time creating eating disorders. There are known cases of muscle pain that may have hindered its marketing. However, the reviews on this product are largely positive. Please consult your doctor before using 5-HTP Mood Positive.

3/5 - (1 vote)
Notify of
Inline Feedbacks
View all comments