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Serenagen Review

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Overview | Formula | Side Effects | Cost | Directions | Bottom Line

With job, academic, social, and financial demands on the rise, stress levels in the general population seem to be rising. Increased stress levels directly increase your body’s production of cortisol, which causes an increase in your blood pressure and heart rate, increases blood glucose, and compromises the immune system.

Luckily, there are several supplements formulated to help with stress management. This review will look at Serenagen, a herbal formula, its benefits, cost, and effectiveness.

Is Serenagen right for you? Does it work? Keep reading this review to find out.


1) Quick Overview

Serenagen is a combination of traditional Chinese herbs formulated to combat high stress levels in the body. It contains extracts from natural herbs like Ginseng, Rehmannia root, Jujube fruit, and Schisandra fruit with many benefits.

These herbs have several properties that may make Serenagen effective in helping you manage stress.

2) The Company Behind Serenagen

Serenagen is manufactured by Metagenics, a United States company that was established in California in 1983. Metagenics has a unique idea of quality and focuses on researching and testing the potency, effectiveness, and safety of every ingredient used.

Metagenics products are retailed in several countries, including Canada, Belgium, and Australia, and include popular supplements like Adreset, Thyrosol, MyoCalm, and Ceriva.


3) What Are Serenagen Ingredients?

Serenagen contains extracts from

  • Rehmannia Root
  • Schisandra Fruit
  • Jujube Fruit
  • Dong Quai Root
  • Chinese Asparagus Root
  • Ophiopogon Root
  • Asian Ginseng Root
  • Chinese Salvia Root
  • Scrophularia Root
  • Poria Fungus
  • Polygala Root
  • Platycodon Root

4) What Does Serenagen Do?

Serenagen works to lower stress levels in the body and has multiple benefits because of its ingredients.

  • Rehmannia Root – Rehmannia root contains Catalpol, a substance that has been shown to protect the brain from ischemia.

  • Schisandra Fruit – Schisandra is an adaptogen, a substance that stimulates resistance to stressors in the body. It also has antioxidative properties.

  • Jujube Fruit – Jujube enhances the activity of acetylcholine, an essential neurotransmitter in the brain, by improving levels of choline acetyltransferase and inhibiting acetylcholinesterase. Jujube fruit can also protect the brain from oxidative stress[1].

  • Dong Quai Root – This herb has anti-inflammatory properties and has been used for centuries in Chinese medicine.

  • Asian Ginseng Root – Ginseng promotes the secretion of nitric oxide, which helps to lower high blood pressure.

  • Chinese Salvia Root – Salvia promotes blood flow and increases circulation in the body.

  • Scrophularia Root – Scrophularia root has anti-inflammatory properties and has also been used to treat some skin disorders.

  • Polygala Root – Polygala contains substances that may help reduce anxiety.

Side Effects

5) Side Effects of Using Serenagen

There are no significant side effects of using Serenagen as most of its ingredients are natural herb extracts. However, stomach upset, dizziness, headaches, and allergic reactions may occur from using Ginseng, Rehmannia, or Salvia root, which Serenagen contains.

Where to Buy?

6) Where to Buy Serenagen?

You can buy Serenagen from the company website or on Amazon.


7) Serenagen Cost

Serenagen costs $29.61 for 60 tablets.


8) Directions For Taking Serenagen

You should take two tablets of Serenagen daily.

Bottom Line

9) The Bottom Line – “Does it Work?”

With its robust blend of natural Chinese herbs, including Ginseng, Salvia, and Rehmannia roots, Serenagen may be an excellent natural stress management formula for you. These ingredients have been used for hundreds of years for their numerous benefits and are generally safe when consumed as recommended.

Also, Serenagen is made by Metagenics, a reputable company that prioritizes consumer health and wellness while maintaining quality, transparency, and potency.

3.4/5 - (17 votes)

Reference Sources

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Albert Grims

Holy maiden! I have been through a lot lately, and the stress almost got the best of me, i was really luck to get a hold of Serenagen as it relieved my heart!


I am definitely calmer and I sleep better however I feel very drowsy during the day. I take the pills before bed should I take them sooner?