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Nutri-Calm Review – Is it Effective?

By Dr. Usmarah Hussain

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Summary | Ingredients | Health Benefits | Side Effects | Warnings | Cost | Where to Buy? | How To Take | Bottom Line

Nutri-Calm is advertised as a natural anxiety supplement to achieve peace of mind and cope better with occasional stress.

Many of us experience anxiety and stress occasionally. Anxiety is a feeling of unease, worry, or fear. It usually occurs as a stress reaction and is often present in people who cannot identify significant stressors in their lives. Anything that places a demand on your body or brain is a stressor. While many people may underestimate the everyday stressors of life, these may keep accumulating to hit mental health and cause various side effects. For such people, using a natural stress-busting formula like Nutri-Calm can help.

Our Nutri-Calm review below will analyze this multivitamin supplement’s most critical elements, starting with the manufacturer and finishing with the claimed benefits, cost per serving, potential side effects, and more.


1) What is Nutri-Calm?

Nutri-Calm is a popular supplement for stress and anxiety relief. The formula developed by Nature’s Sunshine consists of two blends – a multivitamin blend that offers an amalgam of all vitamins that the brain needs, and a proprietary blend that includes several herbal extracts.

According to the manufacturer, the unique blend of B-Complex vitamins, Vitamin C, and herbal extracts added to Nutri-Calm can promote peace of mind and relaxation without any negative effects. As a result, users can better focus on their daily jobs, enjoy an uplifted mood, and increase the overall quality and happiness in their lives.

2) The Company Behind Nutri-Calm

Nutri-Calm is a product of Nature’s Sunshine, a supplement company established in 1972. [1] It claims to be the very first company to encapsulate herbs nearly four decades ago. Now, Nature’s Sunshine is represented by nearly 600.000 distributors and can be found in 30 countries.

The company firmly believes that quality begins at the source; hence, it pays special attention to securing the finest natural materials and herbs from all parts of the world. It also conducts frequent on-site vendor inspections to guarantee that only the purest and cleanest materials are added to its products. Using 40 years of experience, the company integrates these high-quality ingredients into unique, highly-effective products that claim to work even when everything else fails.

According to the company’s official website, it also invests millions of dollars every year to ensure quality assurance. It relies on state-of-the-art equipment, highly- qualified personnel, and evidence-backed testing methods to develop, test, and store its products. At the moment, Nature’s Sunshine has multiple products under its label in the market belonging to categories like detox, weight management, immunity, and beauty.


3) Nutri-Calm Ingredients

Nutri-Calm contains the following active ingredients:

  • Vitamin C (ascorbic acid) 400 mg
  • Thiamin (Vitamin B1, thiamine mononitrate) 20 mg
  • Riboflavin (Vitamin B2) 20 mg
  • Niacin (niacinamide) 40 mg
  • Vitamin B6 (pyridoxine hydrochloride) 20 mg
  • Folic Acid 208 mcg DFE (125 mcg folic acid)
  • Vitamin B12 (cyanocobalamin) 34 mcg
  • Biotin 100 mcg
  • Pantothenic acid (d-calcium pantothenate) 80 mg
  • Choline (bitartrate) 13 mg

And Proprietary Blend containing:

  • Schisandra fruit (Schisandra Chinensis)
  • Inositol
  • Para-Aminobenzoic Acid (PABA)
  • Bee Pollen
  • Lemon Bioflavonoid extract
  • Hops flower extract (Humulus Lupus)
  • Passionflower flower extract (Passiflora Incarnata)
  • Valerian root extract (Valeriana Officinalis)

Other inactive ingredients include cellulose, dicalcium phosphate, vegetable stearic acid, silicon dioxide, and vegetable magnesium stearate.

4) Does Nutri-Calm Work?

In this part of our Nutri-Calm review, we will discuss some of the core ingredients included in the formulation, analyzing how these ingredients can benefit your cognitive health.

Vitamin C is a vital nutrient for health. It helps form and maintain blood vessels, skin, and bones. It is also a potent antioxidant that supports the immune system and is an intricate part of the skin’s defense system.[2][3][4] It’s actively transported to the skin, where it can act as an antioxidant and help strengthen the skin’s barriers.[5] Additionally, Vitamin C supports the production of white blood cells known as phagocytes and lymphocytes, which help defend the body against infection.[6] This essential vitamin may also protect your memory and thinking as you age.[7] Studies suggest that inflammation and oxidative stress in the central nervous system can increase the risk of neurodegenerative diseases, such as dementia, and vitamin C has been proven to counteract these effects. [8][9][10][11]

Next in the ingredients list of Nutri-Calm is B-Complex usually delivers the following eight types of B-Vitamins:


  • Thiamine (Vitamin B1)
  • Riboflavin (Vitamin B2)
  • Niacin (Vitamin B3)
  • Pantothenic acid (Vitamin B5)
  • Pyridoxine (Vitamin B6)
  • Biotin (Vitamin B7)
  • Folic acid (Vitamin B9)
  • Cobalamin (Vitamin B12)

Found naturally in meat, dairy, leafy greens, peas, beans, and whole or fortified grains, B-Complex vitamins play an indispensable role in sustaining good health and well-being. As the building blocks of a healthy body, these vitamins directly impact your energy levels, brain function, and cell metabolism. Moreover, plenty of studies have proven their role in supporting the following: [12][13][14][15][16]

  • Muscle tone
  • Growth of red blood cells
  • Cell health
  • Good eyesight
  • Energy levels
  • Good digestion
  • Healthy brain function
  • Proper nerve function
  • Healthy Appetite
  • Cardiovascular health
  • Hormones and cholesterol production

Passionflower (Passiflora incarnata) is another ingredient of Nutri-Calm with high popularity in traditional medicine.[17] In alternative medicine, the advocates of Passionflower claim that extracts from this herb can help with drug withdrawal symptoms, neuralgia, anxiety, epilepsy, and insomnia.[18] Furthermore, preliminary research quoted by authentic organizations indicates that Passionflower may show promise in treating health concerns like sleep disorders and mild anxiety.[19]

Valerian (Valeriana officinalis) is a plant used for centuries as a herbal remedy to support restful sleep.[20] Its use dates back to the Roman and Greek civilizations and was used by Hippocrates to treat heart trembling, palpitations, headaches, and nervousness. Valerian contains a compound known as ‘valerenic acid,’ which affects GABA (gamma-aminobutyric acid) receptors in the brain. Scientists believe that one of GABA’s purposes is to control the anxiety or fear experienced when nerve cells are overexcited. [21][22] These proven effects on GABA are why valerian root has been added to Nutri-Calm. Some people also consider this ingredient to be a safe and natural alternative to prescription anxiety medications, most especially those like Valium (Diazepam), Ativan (Lorazepam), Xanax (Alprazolam), and Klonopin (Clonazepam), that act on GABA receptors.[23]

In view of the discussion above, Nutri-Calm has a very high likelihood of working effectively to deliver the said benefits.

Health Benefits

5) Nutri-Calm Health Benefits

As per the manufacturing company, regular use of Nutri-Calm can lead to the following benefits:

  • Supports the nervous system;
  • Excellent for occasional stress relief;
  • Promotes calmness;
  • Natural formula that includes a unique blend of ingredients with proven benefits for stress and anxiety;
  • Made in the United States by a reputable and well-known manufacturer.
Side Effects

6) Nutri-Calm Side Effects

Given the ingredients available in this multivitamin supplement, some individuals may experience mild to moderate adverse effects, typically as a response to how their bodies adjust to the product.

Some of these side effects may include the following: [24][25][26]
– Excitability
– Stomach upset
– Headaches
– Mental dullness
– Heart disturbances
– Uneasiness
– Loss of coordination
– Insomnia
– Dizziness
– Confusion
– Liver toxicity
– Drowsiness
– Vomiting
– Nausea
– Loss of appetite

The probability of experiencing these side effects is low and most of them are likely to dissipate on their own with time.


7) Nutri-Calm Product Warnings

Nutri-Calm contains various herbal extracts that may interact with certain prescription medications, including the following:[27][28][29]

  • Sedative medications, such as Phenobarbital (Luminal), Pentobarbital (Nembutal), or Secobarbital (Seconal)
    Alprazolam (Xanax)
  • Medications changed by the liver, such as Ketoconazole (Nizoral), Lovastatin (Mevacor), or Itraconazole (Sporanox)
  • Aspirin
  • Medications used for HIV/AIDS (Protease Inhibitors)
  • Medications used for lowering cholesterol (Statins)
Where to Buy?

8) Where to Buy Nutri-Calm

You can purchase Nutri-Calm from the official Nature’s Sunshine store (naturessunshine.com) or various online retailers such as Amazon, Walmart, or eBay.


9) How Much Does Nutri-Calm Cost?

One bottle of Nutri-Calm (60 tablets / 60 servings) is currently available on the official website for a discounted price of $19.45. The supplement is also available in bottles of 100 tablets each for $29.20.

A “Subscribe and Save” auto-ship program is available on Nature’s Sunshine’s official website. The program offers automatic deliveries (every 30, 60, 90, or 180 days) with free shipping and a 25% discount.

How To Take

10) How to Take Nutri-Calm

As a dietary supplement, take one tablet with a meal three times daily.

11) What Users Are Saying

"This was kind of a waste of money for me, personally. I took one pill, and it made me feel worse, not better. Later, I found out that B vitamins in large doses can actually increase anxiety and panic for some people. I guess it does for me. $28 for one single pill... not really a very good purchase." [Read full review]

---S. Vanhoose

"As a college student, it comes to a lot of stress. So it helps a bit to be able to give my body some vitamin b to manage my stress. I recommend this, but you have to be patient because herbal medicine is a slow and steady process." [Read full review]

---Yovani Munoz

"This did not really do a lot for me. But everyone is different. It may work great for you. If you are considering this, try it and see if it works for you." [Read full review]

---Deb G

Bottom Line

12) The Bottom Line – “Does it Work?”

Nutri-Calm offers some good ingredients for a natural anxiety and stress relief supplement. It contains decent amounts of Vitamin C, a complex of B-Vitamins, and several herbal extracts that may relieve occasional stress and anxiety to induce an overall relaxed and stress-free feeling. Overall, Nutri-Calm is a popular supplement made by a reputable brand. It generally has positive reviews, and it’s available at an affordable price to try.

3/5 - (4 votes)

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