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Life Extension Cognitex Elite Pregnenolone Review

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Overview | Ingredients | Pros & Cons | Cautions | Cost | Suggested Use | Conclusion

Cognitex with Pregnenolone & NeuroProtection Complex is advertised as a superior cognitive enhancement and neuro-protective dietary supplements. The formula manufactured by Life Extension features a combination of brain-specific nutrients such as Phosphatidylserine and Uridine-5′-monophosphate (UMP), plant extracts in a standardized form including Ashwagandha, Rosemary and Hops and other nutrients for the well-functioning of the brain.

The supplement is also advertised as being enriched with Pregnenolone, a precursor of numerous hormones involved in several essential body processes and functions. The manufacturer fails to bring andy actual scientific evidence to support the effectiveness of this synergistic blend, however the majority of the formula’s ingredients have enjoyed much attention from the scientifical world.,

Life Extension is a company which enjoys a great reputation as a dietary supplements manufacturer. The company also operates a non-profit foundation and makes available an affiliate program where anyone can join and contribute to the promotion of the company’s products. The company has been and still is highly involved in developing innovative break-through productss that ultimately lead to progression.

Cognitex with Pregnenolone & NeuroProtection Complex is recommended for adult us exclusively and is claimed to be free of sugar, colors, flavors, and most common allergens. Pregnant and lactating women are advised to consult a healthcare provider prior to use.


1) Quick Overview

Cognitex with Pregnenolone & NeuroProtection Complex contains herbal extracts (standardized concentrations), and other nutrients necessary for the brain to function normally.

Hops is one of the several herbal ingredients included in the formula. The plant has an excellent reputation of being a strong natural sedative, while many research studies have been conducted to study the health enhancing effects of Hops. Most commonly, Hops is considered similar in effects and potency to the Valerian root. The plant acts by relaxing the nervous system and hence allows the user to fall asleep faster. Among the numerous uses of Hops we mentionvarios anxiety disorders, stress, restlessness, and insomnia. There are certain side effects known to be caused by Hops, such as worsening the depression state in people already suffering from this condition.

Vinpocetine is a synthetically derived substance from an herbal source, the plant called Vinca Minor. The extract has been used as a medicine since mid 1960’s an dis particularly effective against memory disorders, cognitive impairment, and a variety of diseases which result from impaired blood circulation. Direct benefits include enhanced concentration and mental alertness and increased energy levels. Vinpocetine can sometimes cause side effects such as stomach, headache, nausea, pain, sleep impairment, and nervousness.


2) Details on Life Extension Cognitex Elite Pregnenolone Ingredients and Uses

Cognitex with Pregnenolone & NeuroProtection Complex contains the following ingredients: Alpha-Glyceryl Phosphoryl Choline (A-GPC), Phosphatidylserine [Sharp-PS GOLD Conjugated Phosphatidylserine-DHA], Pregnenolone, Vinpocetine, Leucoselect Phytosome [containing 50 mg grape seed (Vitis vinifera) procyanidin extract complexed with soy (Glycine max) phospholipids (bean)],
VitaBlue Wild Blueberry (Vaccinium angustifolium) 130:1 Extract (fruit) [std. to 4.9% Total Anthocyanins (7.35 mg)], Sensoril Ashwagandha (Withania somnifera) Extract (root and leaves) [std. to 8% withanolide glycoside conjugates (10 mg)], Uridine-5′-Monophosphate (disodium), Proprietary, NeuroProtection Complex Blend, Perluxan Hops (Humulus lupulus) Standardized Extract (cones), Ginger (Zingiber officinale) Standardized Extract (rhizome), Rosemary (Rosmarinus officinalis) Standardized Extract (leaves), rice bran oil, gelatin, glycerin, soy lecithin, silicon dioxide, carob color, and purified water.

3) What Does Life Extension Cognitex Elite Pregnenolone Do?

The supplement is complex mixture of brain and cognitive function health enhancing substances. The product is free of most common allergens (shellfish, nuts, wheat, yeast, gluten, etc), sugar, preservative, colors, flavors, and other artificial ingredients. It may, however, contain fish and soybeans.

Ashwagandha is one of the most important herbal extracts featured by the formula. The plant has been traditionally used as a medicinal remedy by various Indian and oriental cultures. Today, due to mass popularization, the plant finds uses in an impressive number of dietary supplements. The plant, perhaps most famous for its brain protective effects, has been touted for benefits against stress, insomnia, fatigue, nerve synapses problems and many more. Research has been published in large numbers, and it supports the plant’s benefits against conditions such as Alzheimer’s disease or mild cognitive impairment.

Phosphatidylserine (PS), another important ingredient, is also rather popular as a cognitive enhancer and protector. Among its most frequently advertised benefits we mention: strengthening memory, relieving stress, depression and mood swings and increase concentration and mental sharpness. PS plays an important role in the secretion of several hormones involved in learning and memory. With aging, the brain’s need for Phosphatidylserine increases, as natural supplies decrease. This is why supplementation becomes essential at old age.

The Complex of nutrients advertised by the formula includes a mixture of standardized extracts of Hops and Rosemary, two herbal ingredients with proven health benefits.

Cognitex with Pregnenolone & NeuroProtection Complex is not an FDA approved product, like the great majority of dietary supplements. There are several testimonials available online referencing this formulas, and while most are positive and praise the Effectiveness of the product, there are some who claim the supplement is ineffective. What is being said of this product includes the following:

  • It enhances memory and other aspects of the brain

  • Pretty expensive

  • I noticed no chance in my cognitive function

Pros & Cons

4) Life Extension Cognitex Elite Pregnenolone: Pros and Cons

  • The formulation is free of most common allergens, flavors, colors, and artificial ingredients
  • Consumer testimonials are generally positive
  • The formula is manufactured by Life Extension, a company with a vast market experience

5) What You Need to Know Before Taking Life Extension Cognitex Elite Pregnenolone

  • Rather high price ($80 for a month’s supply)
  • Certain side effects associated with the main ingredients
  • May contain shellfish and gluten

6) Life Extension Cognitex Elite Pregnenolone Cost

This product is offered in bottles of 90 soft-gels, the equivalent of 30 servings, or a month’s supply. There is a 3 capsules a day recommended dose. Sometimes, various retailers may offer certain discounts and price promotions, determining a decrease in the unit price of the formula. The manufacturer mentions of free trial periods or money back guarantee policy terms. There is however a brief mentioning of a return policy within a 12 months period, however there are no details to the commercial conditions which apply in these case.

Suggested Use

7) Suggested Use

Product testimonials regarding Cognitex with Pregnenolone & NeuroProtection Complex are generally positive, however some report limited effectiveness of the product.


8) Conclusion

Like most dietary supplements, Cognitex with Pregnenolone & NeuroProtection Complex too lacks scientific evidence to back up its core advertised benefits. The manufacturer mentions no individual study either which might have been used to test the formula’s effectiveness. It is essentially important that you read the label for every supplement you start to use, in order to determine potential drug interactions or harmful side effects. This supplement has received some good reviews, but there are a few which claim the product does nothing of the advertised benefits. We recommend that you consult a healthcare provider and discuss all these issues prior to use.

You can also try the basic form of this supplement in Life Extension Cognitex Basics.

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Silvester Kane

Unfortunately, I haven’t noticed any benefits so far, not in my memory, concentration capacity or thinking skills. My friend on the other hand, who recommended me Cognitex, said this helped him tremendously. I’ll see what happens in a couple of weeks or so and I’ll let you know.