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Formula 303 Review – Is it Effective?

By Dr. Usmarah Hussain

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Facts | What's Inside? | Side Effects | Contraindications | Price | Buying Options | Suggested Use | Final Thoughts

Formula 303 by Dee Cee Labs is promoted as a natural and safe supplement for support against rising stress and anxiety levels. These anxiety and stressful thoughts are normal if they do not interfere with day-to-day activities. The human body is equipped to fight them and keep them under control most of the time. However, for some people, the stress levels may become excessive, intense, or persistent to the extent that it starts affecting the overall quality of life. [1] [2]

For such people, Formula 303 claims to provide mental peace and calm by controlling ongoing feelings of panic, intense stress, and anxiety. Keep reading this in-depth Formula 303 review that will analyze different aspects of the product to give the verdict.


1) Formula 303 Quick Facts

Formula 303 is advertised as an all-natural relaxant that promises to reduce stress, anxiety, muscular spasms, restlessness, muscle & tissue pain, low back pain, menstrual cramps, and neck & shoulder pain. The formula consists of three active ingredients – Valerian root extract, Passiflora extract, and Magnesium carbonate, which are commonly found in many renowned stress-relief products in the market.

This all-natural homeopathic solution is available in the form of tablets which are easy to take and include in daily life. All batches are manufactured within the United States in an FDA-registered facility under strict GMP compliance to ensure quality and efficacy.

2) The Company Behind Formula 303

Formula 303 is produced by the American supplement manufacturer Dee Cee Labs.[3] In 1962, Harry F. Hester and his family founded this business to help people strive for a healthier life through high-quality nutritional supplements enriched with minerals, vitamins, herbal extracts, and other nutrients.

Today, Dee Cee Labs is based just out of Tennessee, and it makes a variety of other supplements and vitamins, including:

  • Maxi Snooze
  • Black Cohosh Formula 182
  • Dee-Tox 201
  • Formula 19 Multivitamin & Multimineral
  • Lycopene 15 mg
  • Ultra V M
  • Meno-2.5
  • Vita-Women Time Release

According to the official website, every product available through Dee Cee Labs is manufactured in a state-of-the-art, FDA-registered facility and only chooses the best natural ingredients to preserve potency and deliver on its promises without any side effects.

What’s Inside?

3) What’s Inside Formula 303?

Unlike other stress-relief products that include tens of complicated ingredients, Formula 303 has kept its formulation simple by including the following three ingredients in the core formula:

  • Valerian root extract: A centuries-old ingredient used by people to relieve mood disorders and calm nerves.
  • Passionflower extract: An ingredient with tranquilizing properties that promote better sleep while keeping nervousness in check.
  • Magnesium carbonate: An essential mineral needed for optimal development, stabilization, and function of nerve cells.

4) Does Formula 303 Work?

One crucial aspect to check before evaluating a formula’s effectiveness is the amounts of each active ingredient present in the said formula. Unfortunately, this quantification of ingredients is not possible with Formula 303 as the company has not provided accurate information regarding dosage. The product label states that each tablet contains six parts Valerian root (Quad-Strength) 1X, three parts Passiflora (Quad-Strength) 1X, and one part Magnesium carbonate 1X. The information stated before is vague and doesn’t tell much about each active ingredient’s exact amount.

That said, let’s take a closer look and see how these three ingredients can affect the human body.

Valerian (Valeriana officinalis) is a plant that grows in parts of Asia and Europe. Extracts from this plant’s root have been used for centuries as a herbal remedy to support restful sleep.[4] The use of Valerian root dates back to the Roman and Greek civilizations, where Hippocrates used it to treat heart palpitations, headaches, trembling, and nervousness. Valerian contains a compound known as ‘valerenic acid,’ which affects GABA (gamma-aminobutyric acid) receptors in the brain. Scientists believe that one of GABA’s purposes is to control the anxiety or fear experienced when nerve cells are overexcited.[5][6] In fact, Valerian root has been touted by some as a safe and natural alternative to prescription anxiety medications, such as Ativan (Lorazepam), Klonopin (Clonazepam), Xanax (Alprazolam), and Valium (Diazepam) that act on GABA receptors.[7]

Passionflower (Passiflora incarnata) is another plant that has been used for centuries to treat various health conditions. In alternative medicine, its supporters claim that the ingredient helps with neuralgia, insomnia, epilepsy, anxiety, and other conditions associated with high firing and activity levels in the brain.[8] However, more clinical data is needed to support the therapeutic use of Passionflower. While the plant has been utilized for centuries as a mild sedative, the National Center for Complementary and Integrative Health (NCCIH) believes that the scientific evidence to support its efficacy is insufficient.[9] Some preliminary research quoted by the NCCIH indicates that Passionflower may show promise in treating health concerns like sleep disorders and mild anxiety.[10] However, the results are far from conclusive and need further research to determine whether these claims have merit.

Magnesium carbonate is a white, powdery compound that occurs naturally as magnesite and dolomite and is extensively marketed as a health supplement. Its active ingredient is magnesium, a mineral that the body requires to function efficiently. According to recent research, magnesium is involved in more than 600 reactions in the body, including:[11][12]

  • Protein formation
  • Energy creation
  • Muscle movements
  • Gene maintenance
  • Nervous system regulation

It plays a role in metabolism and helps transport potassium and calcium ions across the cell walls. Healthy magnesium levels are crucial to nerve function, muscle contraction, heartbeat, and healthy bones.[13] As a supplement, it is advertised to treat sleep troubles (restless leg syndrome and insomnia) and improve athletic performance. Low magnesium levels, on the other hand, have been linked to attention deficit hyperactivity disorder (ADHD), osteoporosis, irritability, anxiety, and even depression.[14] [15]

In light of the information mentioned above, the ingredients in Formula 303 make it a potentially effective supplement to calm down a nervous mind and relieve body aches and pains. However, the discrepancy in its ingredient dosages remains a valid concern and may raise some doubts regarding how effective it truly is.


5) Formula 303 Benefits & Results

The claimed benefits of using Formula 303 include the following:

  • It helps with jitters and nervousness
  • It helps with sleep disorders
  • It provides relief from anxiety and stress
  • It alleviates muscle spasms
Side Effects

6) Side Effects of Using Formula 303

Formula 303 contains only three active ingredients which are safe to use when taken as recommended.
Most clinical studies have shown that Valerian root is well-tolerated and safe for short-term use. If any, side effects tend to be mild and may include:[16]

  • Dizziness
  • Headaches
  • Upset stomach
  • Itchiness
  • Vivid dreams
  • Dry mouth
  • Daytime drowsiness

Although Passionflower is generally considered safe, incidences of the following side effects have been reported:[17] [18]

  • Vasculitis
  • Nausea
  • Rapid heart rhythm
  • Vomiting
  • Loss of coordination
  • Dizziness
  • Drowsiness
  • Impaired cognitive function

Due to a lack of research, little is known about the safety and effects of using Passionflower supplements in the long term. According to the NCCIH, its consumption is “generally considered safe but may cause drowsiness.” Keep in mind that the side effects mentioned above are usually mild and do not occur in all users.



7) Formula 303 Warnings and Precautions

Formula 303 contains Valerian root extract, which is broken down in the liver by an enzyme known as cytochrome P450 (CYP450). This may interfere with the effectiveness of certain prescriptions, which are also broken down by the similar enzyme, such as the following:

  • Statin drugs, such as Lipitor (Atorvastatin) or Mevacor (Lovastatin);
  • Antifungal drugs, such as Diflucan (Fluconazole) or Sporanox (Itraconazole);
  • Allergy medications, like Allegra (fexofenadine);
  • Cancer medications, like Etopophos (Etoposide), Camptosar (Irinotecan), STI571, Velban (Vinblastine), Abraxane (Paclitaxel), or Vincasar (Vincristine).
Buying Options

8) Where to Buy Formula 303 in the United States?

Formula 303 is available for purchase from several online stores like Amazon and Pure Formulas. You can also purchase the supplement from the official Dee Cee Labs store (dclabs.com) for the most authentic product free from scams and other risks.


9) Formula 303 Price

Formula 303 is available in the following three highly-affordable packages:

  • 45 tablet bottle for $17.50
  • 90 tablet bottle for $33.00
  • 250 tablet bottle for 76.00

The cheap prices make the supplement easier to use in the long run.

Suggested Use

10) Suggested Use

The suggested use for Formula 303 may vary depending on the intended purpose:

  • As a muscle relaxant – take two (2) tablets every three hours until relief.
  • For tension and stress – take two (2) tablets with each meal and two (2) at bedtime.

11) What Users Are Saying

"I went without these for a couple of weeks and noticed a huge difference in my mood, not in a good way. I was irritable and short-tempered. I started taking these for my back as a muscle relaxant originally, but I am now taking it as a mood relaxant. The smell is absolutely horrible, but the benefits outweigh it, so I'll keep buying and taking these." [Read full review]

---Marlize T.

"I broke my neck back in the Gulf War, so C1 doesn't like staying in place. My chiropractor originally recommended this (3 tablets) to prevent muscle spams as bruising on the spinal cord heals. It is an absolute necessity to keep around because, as a software developer, I cannot work for 5+ days if I take the narcotics that the VA and other doctors prescribe. " [Read full review]

---Eric B.

"My chiropractor recommended me these pills for chronic shoulder/neck pain. I take two capsules in the morning, noon, and night, and they have decreased my pain levels moderately. If I am at a 5 level pain, it might knock it down to a 3. They are not magic, but I have tried many things, including regular over the counter pain medicines like Advil, Tylenol, etc., to much less effect. I would recommend anyone with ongoing pain issues to try these!" [Read full review]

---Brittany Geer

Final Thoughts

12) Final Thoughts on Formula 303

Dee Cee Labs Formula 303 is an all-natural supplement with overwhelmingly positive reviews from users who have personally tried and tested it. These reviews confirm how effective the formula is for alleviating mild pain and reducing a calm state of mind. The ingredients in the formula have a centuries-old history of use for the required benefits, making the supplement worth a try.

3.9/5 - (14 votes)

Reference Sources

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Pamela Abshire

I love Formula 303. They have helped with muscle spasms and chronic pain. My opioid receptors do not work, so traditional pain meds don’t help me. My chiropractor suggests them, and surprisingly they actually help. They also help me sleep for several hours instead of waking up every couple of hours. The only downside, and it’s a big one, is the horrible smell. It smells like dog puke…no joke… straight-up dog puke. Luckily it doesn’t leave a nasty taste in my mouth. But it will leave a smell on your hand. So I do this: I pour 2 pills from the bottle into the cap, pour a little of my drink in my mouth, pour the pills in, and then more drink to swallow them down. I know that seems like a lot, but I do it because they actually help. After years with no relief, these pills are great!

Title for your comment
Horrible smell but so worth it!
Have you tried this product?

I have been struggling with a sore jaw muscle and TMJ. I started taking Formula 303 and it has helped my jaw muscle relax and I have less pain. I take 1 or 2, two or three times a day. I notice my discomfort returning steadily if I do not take them. It’s been very helpful!

Title for your comment
Tmj and sore jaw muscle
Have you tried this product?

Have been using these for years. My chiropractor gave them to me for my tension in the neck. Wonderful product. I recommend these to everyone who complains about tension. And also for trouble sleeping at night.

Pat Crandall

Im on my second bottle of 90. Don’t have to take ibuprofen any more


I take it and within 20 minutes I’m out!


I tried it for the first time last night and couldn’t sleep a wink plus it made my nose itch all night!


It really is awesome!!! I’m not big on taking pills but after taking 303, I feel soo much better and definitely less stress. 5 stars plus for me!!!!!!


Love 303! it works! and I tried to give it 5 stars! and the page won’t let me!!


Take a drink of water and just swallow. You won’t taste anything at all.


inhale and hold your breath, swallow then exhale.


I just tried it today for the first time. Within twenty minutes I felt results. I was much more relaxed and the pain in my arthritic foot became less. I had just had a long day of walking on my foot and it was on a pain scale of seven to eight. It’s been a hour and a half after my first dose and my pain level, swelling is down to 3-4 . I believe it is working!


This product works for me. Going through an anxious period and also dealing with insominia. Started the product two nights and immediately takes the edge off and has allowed me two straight nights of good sleep as well.


I love this product! I was given it by my chiropractor after a back injury. I now use it on occasion after a stressful day or long day on my computer, (1/2 a tablet after dinner) for a perfect nights sleep, It is strong, so if you take at bedtime and do not have 8 hours to sleep, you may wake up groggy or grumpy, that’s why I take it after dinner :)

Alice Smith

I’m a fitness instructor and though I’m familiar with all the rules about exercising, I sometimes tend to overdo it, especially if I have several private classes in a day. Formula 303 helps relieve my muscle and joint pains and I actually noticed I also sleep better after I take it.