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EndoPlus Review – Is it Effective?

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Facts | What's Inside? | Claims | Cautions | Cost | How To Take | Does it Work

EndoPlus is a dietary supplement advertised to alleviate restlessness, anxiousness, and insomnia symptoms associated to neurotransmitterover-stimulationor increased GABA excretion. The formula manufactured by NeuroScience comes in the form of an easy to administrate spray and contains two key ingredients: the amino-acid Theanine and 5-HTP (5-hydroxytryptophan). The formula has a nice root beer flavor and is advertised as easily absorbed for fast, long lasting results. Both Theanine and 5-HTP have been scientifically studied for their brain relaxation effects, although there is no evidence that the combination proposed by the manufacturer of this formula may actually produce the advertised results.

The manufacturing company NeuroScience is a company based in Wisconsin, United States and was established in 1999. The company offers endocrine, neurological and immune system products which use ingredients in the spectrum of neurotransmitter stimulants and precursors, enzymes, and modulators. In addition, NeuroScience focuses on providing assessment tests and markets for a variety of neurological and immune system functions. They’re also the company behind GABA supplement TravaCor.

The manufacturer recommends that EndoPlus is used exclusively by adults, except people who are in an advanced stage of depression or anxiety episode and who should consult a healthcare provider before self-administrating any treatment. Pregnant and nursing women are also advised caution when using this product.


1) EndoPlus Quick Facts

EndoPlus contains 5-HTP and Theanine as core ingredients.

5-HTP is a substance extracted from the Griffonia simplicifolia plant. Also, it is naturally produced by the body to synthesize two neurotransmitters, called Melatonin and Serotonin. Published research indicates that depletion of Serotonin has been found in people who go through depression and several other mood affecting disorders including Bipolar Disorder or postpartum depression. 5- HTP may also be used to treat other conditions including obesity, insomnia, craving reduction, addictive behavior of any sort and PMS (premenstrual Syndrome). There are certain concerns regarding the safety of 5-HTP as a dietary supplement; there is no recommended daily value recommended yet because of this.

Theanine is an extract of the green tea leaves with potent calming effects. It also exhibits powerful antioxidant properties and has the structure of an amino-acid. Theanine is promoted in numerous dietary supplements and advertised to treat a wide array of diseases, from symptoms of PMS to stress. The amino-acid’s relaxing properties make it useful in treating anxiety related symptoms, ADD or ADHD, learning and concentration issues, and many others.

What’s Inside?

2) What’s Inside EndoPlus?

EndoPlus contains the following ingredients: Suntheanine (L-theanine), 5-hydroxytryptophan (from Griffonia simplicifolia seed extract), Purified Water, Fructose, Natural Flavors, Hydroxylated Lecithin, Potassium Sorbate (as preservative) and Citric Acid.


3) EndoPlus Claims

  • Easily absorbed, spray form
  • Positive consumer reviews
  • Natural ingredients
  • Tested and researched key ingredients

4) What You Need to Know Before Taking EndoPlus

  • Limited number of consumer testimonials
  • Lack of a money back or return policy
  • High price for a month’s supply

5) EndoPlus Cost

SeroTrex’s price range may vary a lot, depending from where you choose to purchase it. The official site only allows registered healthcare practitioners to order any of the supplements. However, the formula is available on several other online retailers, without such restrictions.

Overall, this is an expensive supplement, and some people may not be able to afford it. If you choose to place your order online, please take into consideration the shipping costs as well. The company’s website does not, however, reveal these costs which are probably listed after logging in and placing the order.

How To Take

6) How to Take EndoPlus

Customers claim EndoPlus has helped with their adrenal fatigue symptoms, sleep problems and overall restlessness and nervousness. The number of reviews is limited. Each 60 ml spray contains approximately 84 doses. A daily serving is one spray (dose).

Does it Work

7) Bottom Line – Does It Really Work?

Brain neurotransmitters play a great role in the overall functioning of the brain and the health of the cognitive function. GABA, the chief inhibitory neurotransmitter, is involved in regulating mood and plays a crucial role in the evolution and development diseases, such as depression or anxiety. Serotonin depletion on the other hand is also a factor of these two neurological conditions. EndoPlus addresses restlessness, insomnia, and anxiousness by balancing the levels of these neurotransmitters. The formula is not FDA approved and has not been independently researched. Given the severity of these conditions, we advise that you ask specialized advice prior to use.

3/5 - (1 vote)
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Neil B.

I still can’t decide between endoplus and my previous supplement. I see many people praising this one so I’m going to give it a try.


The world seems a better place now. I sleep better and wake up ready to face the world. I’m calmer and more relaxed…