Home » Reviews » Mood Supplements » Doctor’s Best SAMe Review

Doctor`s Best SAMe Review – 7 Facts You Need to Know

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Summary | Formula | Pros & Cons | Precautions | Cost | Directions | Bottom Line

SAMeis advertised as a science based nutritional supplement designed to enhance mood and neural function. The supplement is manufactured by Doctor’s Best. The company mentions joint comfort and mobility and liver and detoxification support as side benefits of the formula.Doctor’s Best is located in California, United States and was founded in 1990. The company offers therapeutic nutrition solutions based on traditional medicinal knowledge and current scientific research. The product portfolio includes products which target a variety of ailment claims, including brain and memory, mood enhancement or sleep and relaxation. SAMeis recommended exclusively to adults. People diagnosed with bipolar disorder (or manic depression) are advised to avoid SAMe supplementation, as it may aggravate the manic phase.


1) What Are SAMe Ingredients?

SAMeincludes the following ingredients: S-Adenosyl Methione, cellulose gel, Methacrylic Acid Copolymer, Compritol 888ATO, Talc, Triethyl Citrate, Titanium Dioxide, Magnesium Stearate, Manitol, Glycerol Palmitostearate, Silica, Medium Chain Triglycerides, Sodium Starch Glycolate, and Iron Oxide.

2) Does SAMe Work and it is Safe?

SAMe is a single ingredient formula; particularly it contains a derivate of the amino acid Methionine called SAMe. SAMe is one of the most active donors naturally produced by the body and has received increased attention over the past few decades. Research revealed important functions of SAMe in mood and cognitive health, joint mobility, liver, energy production and other vital processes.

Essential functions of the nervous system are due to SAMe’s role in the secretion process and metabolism of Serotonin, Melatonin and Dopamine, key brain neurotransmitters which regulate behavior, mood, and emotions. SAMe has been the topic of research investigating mood disorders including major depression or dysthymia. Several studies have shown that it can improve symptoms associated with anxiety disorders including panic attacks or social anxiety. However, the number of clinical research is extremely limited, and SAMe is not approved by the FDA as depression or anxiety treatment.

Similarly, it may positively impact memory and learning capacity, aging, sleep, aggression mood, and motivation.

SAMe is mostly produced and active in the liver, where it supports liver detoxification and bile secretion process. Low levels of SAMe may be an indicator of liver dysfunction and lead to liver dysfunction.
Long term side effects of SAMe have not been systematically studied. There is concern that high doses may lead to anxiety, restlessness, and insomnia, gas, vomiting, diarrhea, dry mouth, sweating, dizziness, constipation, headache, anxiety, and nervousness. Special precautions are recommended to people suffering from bipolar disorder and Parkinson’s disease.

The manufacturer recommends taking one tablet daily away from food. The formula does not contain milk, egg, corn, soy, wheat, gluten sugar, sweeteners, or preservatives.

There are testimonials posted online about SAMe. What is being stated includes:

  • I noticed a difference in my mood swings

  • Great antidepressant

  • Did not work for my shoulder arthritis

  • It keeps me focused and balanced

Pros & Cons

3) SAMe: Pros and Cons

  • SAMe has been extensively researched and proven effective in some areas;
  • Affordable (2 month’s supply costs approximately $20);
  • Does not contain milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, or preservatives.


4) Precautions of SAMe Use

  • Not sufficient data on long-term supplementation effects;
  • Contraindicated for people with Bipolar Disorder;
  • Mixed consumer reviews.


5) SAMe Cost

SAMe is available in bottles of 30 and 60 enteric-coated capsules. The price of the formula is similar to other SAMe featuring products. A bottle of 30 capsules, meaning a month’s supply, costs roughly $40, at list price. This is a rather high price. However, promotions and discounts are usually available, and you could purchase the supplement at a lower cost.

The formula can be purchased from online or local retailers. A section of the manufacturer’s website id dedicated to retailer identification, using the ZIP code.


6) SAMe Directions

SAMecontains 200 mg SAMe (S-Adenosyl Methionine), a compound naturally produced by the body and known as one of the most active methyl donors. SAMe has been extensively researched over the past years and evidence shows it plays an important role in the immune system, cell membranes health and liver function. Additionally, research revealed it participates in the secretion and metabolism of key neurotransmitters such as Serotonin, Melatonin and Dopamine. By doing so, SAMe may potentially be effective in health areas that these neurotransmitters are known to regulate. For instance, SAMe is tested for benefits against depression, anxiety, obsessive-compulsive disorder or panic, known to be caused by Serotonin deficiencies. Similarly, it may positively impact memory and learning capacity, aging, sleep, aggression mood and motivation. The largest amounts of SAMe are produced and active in the liver. This is why low levels may indicate liver dysfunction and lead to liver damage. Supplementation is generally used to reduce inflammation and dysfunction of the liver. Long term side effects of SAMe are currently unknown, however high doses may lead to anxiety, restlessness and even insomnia. Special precautions are recommended to people suffering from bipolar disorder. The manufacturer recommends taking 1 tablet daily away from food, although an exact daily dose has not been established yet. Consumer reviews of SAMeare mixed.

Bottom Line

7) Our Bottom Line

SAMecontains a single active ingredient, SAMe. Research revealed that this naturally occurring compound is able to offer liver protection, joint function support and mood enhancement. While large scale research is required to confirm some of SAMe’s benefits, it can be argued that SAMe will work to deliver on its advertised benefits at least for some consumers. Consumer reviews received are mixed: while some consumers report almost immediate results, others say this is nothing more than a placebo. All things considered, we believe you should discuss all details with a healthcare provider if you decide to use SAMe.

5/5 - (1 vote)
Notify of
Inline Feedbacks
View all comments
Ann Johnstone

I’ve been taking SAMe 200 mg per day for over a year now, and I find it excellent as a mood stabilizer and gentle but consistent anti-anxiety treatment. And that has been in the face of extreme stressors! As a nurse, I have found products such as these so much better than the majority of drugs, which often come with severe side effects.

Thelma Wright

I began taking Doctors Best SAMe a few ago. Prescription antidepressants can’t compare with it and I have tried more than a few, after losing my husband to cancer. I personally recommend taking it taken around noon, on a empty stomach. I feel it better absorbs that way. I wish it weren’t this pricey, but it’s still the best on the market for me.