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Unisom SleepGels Review – 10 Facts to Consider

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Facts | Nutrition Info | Pros & Cons | Side Effects | Cost | Where to Buy? | Directions | Does it Work

Unisom SleepGels is marketed as a non-prescription supplement that promotes a restfull night’s sleep. According to the manufacturer, the product helps with falling asleep faster and getting a more sound sleep.

The manufacturer claims the formula was tested and successfully used by millions of patrients since 1978, when it first appeared on the market.

The manufacturer is a U.S. company named Chattem, whose product range includes Unisom SleepGels, Unisom SleepMelts, Unisom SleepCaps, and Unisom PM Pain.

Our Unisom SleepGels review discusses the primary ingredient in this formula that makes it effective, its uses, potential benefits, and pros and cons. Keep reading this article to find out how Unisom SleepGels can help you get a better night’s rest.


1) Unisom SleepGels Quick Facts

Unisom SleepGels is a single-ingredient nonprescription sleep aid. According to the manufacturer, the product is recommended to relieve occasional sleeplessness.

The core ingredient is Diphenhydramine Hydrochloride, which acts by blocking the effects of histamine, a naturally occurring neurotransmitter that is essential in modulating sleep.

Anti-histamines (or histamine inhibitors) are generally used to help induce the sleeping state.

According to the manufacturer, Diphenhydramine hydrochloride has a proven record of promoting safe, restful sleep and is FDA-approved as an over-the-counter drug.

The manufacturer claims Unisom SleepGels is the first sleep-aid in its category to come in an easy-to-swallow softgel form.

Although rare, typical side effects may include constipation, diarrhea, drowsiness, nose, dry mouth or throat, excitability (especially in children), headache, dizziness, nervousness, loss of appetite, restlessness, nausea, etc.

Nutrition Info

2) Ingredients of Unisom SleepGels

Unisom SleepGels includes the following ingredients: Diphenhydramine Hydrochloride, blue 1, gelatin, glycerin, polyethylene glycol, polyvinyl acetate phthalate, propylene glycol, sorbitol, titanium dioxide, and water.

  • Diphenhydramine is a histamine blocker commonly used to treat allergies.

Histamine keeps you awake by inhibiting neurons that help you sleep and stimulating cortical neurons that cause arousal.

By blocking histamine’s effect, diphenhydramine reduces arousal levels and helps you feel sleepy and fall asleep. Diphenhydramine also treats symptoms of allergic reactions driven by histamine.

Overall, Diphenhydramine can

  • Help relieve occasional sleeplessness
  • Alleviate insomnia
  • Reduce symptoms of allergic reactions

3) Does Unisom SleepGels Work?

As stated above, Unisom SleepGels is advertised as a highly effective sleep aid that does not require a prescription. The main ingredient, Diphenhydramine Hydrochloride, is an antihistamine commonly found in sleep aids.

This ingredient is a well-known sedative which is why it is promoted to be able to work to help users get a good night of sleep.

However, while many clinical studies have been conducted on Diphenhydramine Hydrochloride, there is little evidence to support the manufacturer’s claims regarding this formula. On the other hand, this product has been around for almost 30 years and has received numerous positive reviews and testimonials, which is encouraging.

The product is non-habit forming and can be used for long-term treatment. According to the packaging information, Unisom is safe for children over 12 years of age, but only under close parental supervision.

Pros & Cons

4) Unisom SleepGels: Pros and Cons


  • FDA-approved core ingredient
  • Rapid acting formula
  • Rare side effects
  • The product comes in an “easy to swallow” administration alternative
  • Many positive consumer reviews


  • May cause drowsiness or dry mouth
Side Effects

5) Unisom SleepGels Side Effects

Diphenhydramine, the primary ingredient in Unisom SleepGels, may cause drowsiness, nausea, or dry mouth and throat.

Where to Buy?

6) Where to Buy Unisom SleepGels

You can purchase Unisom SleepGels from online retailers like Amazon, CVS, and Walmart.


7) How Much Does Unisom SleepGels Cost?

Each bottle of Unisom contains 100 soft gels and costs $15.68. However, prices may vary by retailer. One hundred softgels is usually enough for three months of treatment at the recommended dose of one soft gel per day.

The average soft gel price makes Unisom SleepGels an excellent deal.

Note that shipping costs may apply based on the retailer.
This product can also be purchased over the counter from various pharmacies to save on shipping charges.


8) Unisom SleepGels Directions

Recommended dose (for adults and children 12 years of age and over) is one softgel (50 mg) at bedtime if needed or as prescribed by a doctor.

9) Of the Same Product Line

Unisom SleepTabs, SleepMelts, and SleepMinis are also available for purchase.

Does it Work

10) Bottom Line – Does It Really Work?

Unisom SleepGels is a non-prescription formula designed for people dealing with occasional night-time sleeplessness. The core ingredient, Diphenhydramine, has been FDA-approved and is known for its sedative properties.

The product is not recommended for children under 12 years of age and should not be taken during periods of alcohol consumption.

People suffering from breathing problems (such as emphysema or chronic bronchitis), glaucoma, or those having trouble urinating due to an enlarged prostate gland should exercise caution and only use Unison SleepGels if directed by a physician.

Overall, Unisom SleepGels has received many positive consumer reviews that praise its effectiveness and the rapidity with which it acts. However, individual results may vary.

2.7/5 - (3 votes)
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