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Nature Made CoQ10 Review – Is it Effective?

By Sasha de Beausset Aparicio, MSc

Reviewed by Rebecca Williams, MD, MA, MB, BChir

Last Updated:

Evidence Based | Facts | Nutrition Facts | Health Benefits | Contraindications | Cost | Where to Buy? | Dosing | Does it Work

Co-enzyme Q10 is a dietary supplement mostly used as an antioxidant and energy level enhancer. CoQ10 is produced by the human body and is used by the cells for growth and maintenance. CoQ10 levels decrease by age, thus supplementing can be considered beneficial by slowing down cellular aging and providing the body with increased daily energy levels.

There are many dietary supplements with CoQ10. In this review, we will talk about Nature Made’s CoQ10.


1) CoQ10 Quick Facts

CoQ10, or Coenzyme Q10, is a substance present in every cell of the human body, particularly areas that are highly vascularized, such as the heart, brain, and liver. Coenzyme Q10 is found in three forms of oxidation: fully oxidized, semiquinone (half oxidized – half reduced), and fully reduced. This property enables the substance to perform both as a component in the transportation of electron impulses and an antioxidant.

Due to its potent properties as an antioxidant Coenzyme Q10 has been successfully used in maintaining a healthy cardiovascular system, with strong evidence linking heart failure with deficiency of the enzyme. It is sometimes used in the treatment of migraines and high blood pressure. Some research suggests that CoQ10 may help reduce (LDL) and total cholesterol levels in people with diabetes.

2) The Company Behind CoQ10

The supplement is manufactured by Nature Made, a sub-division of Pharmavite. Nature Made has been operating since 1971, providing high-quality, low-cost products, aiming to improve people’s health. You can buy their products directly through their website or find a local store using their website’s tool.

Nutrition Facts

3) CoQ10 Nutrition Facts

Nature Made’s CoQ10 comes in different content soft gels (100mg, 200mg, and 400mg), as well as 100mg gummies and 100mg soft gels with Black Pepper Extract, which may boost absorption.

A typical daily dose is 100mg – 200mg but may go up to 1000mg.

Other ingredients of Nature Made’s CoQ10 supplements are:

  • Soybean Oil
  • Gelatin
  • Glycerin
  • Water
  • Rapeseed Lecithin

You can also find CoQ10 as a standalone ingredient. If interested, check out our GNC CoQ10 review.

4) Is CoQ10 Right for You?

Some studies show that CoQ10 may lower blood pressure. CoQ10 is also used to treat heart failure and other heart conditions.

Other studies show that CoQ10 may slow down the progression of Alzheimer’s disease and treat the side-effects, of taking statin-type cholesterol drugs such as muscle pains and liver problems.

Although CoQ10 is sold as a daily energy improvement supplement, there is no evidence that it will boost energy in a typical, healthy person.

Health Benefits

5) CoQ10 Health Benefits

Nature Made’s CoQ10 is a formula based on the antioxidant properties of Coenzyme Q10. According to the manufacturer, this formula may decrease oxidative stress, improve heart condition and slow down cellular aging.

Co-enzyme Q10 is a substance found in every cell of our bodies, being essential for many important reactions such as the production of energy at a cellular level by the mitochondria. Scientists have found that cells of highly vascularized organs such as the heart, liver, muscles, and brain contain significantly higher amounts of Co-enzyme Q10 than other cells. This led to a series of tests that found out that this substance is a powerful antioxidant that can prevent cellular damage caused by free radicals.

Research shows that levels of this Co-enzyme Q10 in the cells seem to decrease with age. Thus, the cellular aging process may be slowed down to some extent by maintaining an adequate quantity of Co-enzyme Q10 inside our cells. That is the main reason most beauty products and anti-wrinkle creams contain high amounts of Co-enzyme Q10, along with Vitamin C.

Overall, Nature Made’s CoQ10 is a great choice of a CoQ10 supplement.

  • Its price is affordable. A two-month supply costs around $25.
  • It’s available in different concentrations.
  • It has no added color, flavor, preservatives, starch, or gluten.

6) CoQ10 Warnings and Precautions

Based on the official directions, Nature Made’s CoQ10 may cause health complications for people during pregnancy, when nursing or taking blood thinning and blood pressure medication. Consult your physician before use.

Where to Buy?

7) Where to Buy CoQ10

You can buy Nature Made’s CoQ10 from their official website and Amazon.


8) CoQ10 Cost

Nature Made’s Co-Enzyme Q10 price varies depending the softgel concentration. Based on their official website:

  • 40 softgels of 100mg cost $26.39
  • 40 softgels of 200mg cost $41.99
  • 40 softgels of 400mg softgels cost $52.49

The price varies from other retailers, such as Amazon. Please note that this formula is sold in containers of various sizes. The larger bottles are more expensive, but the price-per-capsule is lower.


9) CoQ10 Serving Size

For best results, Nature Made recommends taking 100-400mg daily, with a meal.

Does it Work

10) Bottom Line – Does It Really Work?

Coenzyme Q10 is a heavily researched substance, with years of scientific research behind it. Overall, it is a harmless supplement, with no dangerous side effects and potential benefits to people who experience decreased physical performance, high blood pressure, or other heart conditions. People who take statin-type cholesterol drugs may experience fewer side effects when supplementing with CoQ10.

Nature Made is a potentially good choice when compared to other CoQ10 supplements, as its ingredients are transparent, with nothing more than CoQ10 and the ingredients needed to produce the soft gels.

It is considered safe as a supplement. However, it should be taken under a doctor’s supervision.

4.1/5 - (11 votes)
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